دورية أكاديمية
Association of Coagulation Activation with Clinical Complications in Sickle Cell Disease
| العنوان: | Association of Coagulation Activation with Clinical Complications in Sickle Cell Disease |
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| المؤلفون: | Ataga, Kenneth I., Brittain, Julia E., Desai, Payal, May, Ryan, Jones, Susan, Delaney, John, Strayhorn, Dell, Hinderliter, Alan, Key, Nigel S. |
| المصدر: | PloS One, 7(1) |
| سنة النشر: | 2012 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Humans, Biomarkers, Antithrombins, Multivariate Analysis, Anemia, Sickle Cell, Thrombin, Female, Male, Cell-Derived Microparticles, Fibrin Fibrinogen Degradation Products, L-Lactate Dehydrogenase, Adult, Blood Coagulation, Platelet Activation, Demography |
| الوصف: | BackgroundThe contribution of hypercoagulability to the pathophysiology of sickle cell disease (SCD) remains poorly defined. We sought to evaluate the association of markers of coagulation and platelet activation with specific clinical complications and laboratory variables in patients with SCD.Design and MethodsPlasma markers of coagulation activation (D-dimer and TAT), platelet activation (soluble CD40 ligand), microparticle-associated tissue factor (MPTF) procoagulant activity and other laboratory variables were obtained in a cohort of patients with SCD. Tricuspid regurgitant jet velocity was determined by Doppler echocardiography and the presence/history of clinical complications was ascertained at the time of evaluation, combined with a detailed review of the medical records.ResultsNo significant differences in the levels of D-dimer, TAT, soluble CD40 ligand, and MPTF procoagulant activity were observed between patients in the SS/SD/Sβ0 thalassemia and SC/Sβ+ thalassemia groups. Both TAT and D-dimer were significantly correlated with measures of hemolysis (lactate dehydrogenase, indirect bilirubin and hemoglobin) and soluble vascular cell adhesion molecule-1. In patients in the SS/SD/Sβ0 thalassemia group, D-dimer was associated with a history of stroke (p = 0.049), TAT was associated with a history of retinopathy (p = 0.0176), and CD40 ligand was associated with the frequency of pain episodes (p = 0.039). In multivariate analyses, D-dimer was associated with reticulocyte count, lactate dehydrogenase, NT-proBNP and history of stroke; soluble CD40 ligand was associated with WBC count and platelet count; and MPTF procoagulant activity was associated with hemoglobin and history of acute chest syndrome.ConclusionsThis study supports the association of coagulation activation with hemolysis in SCD. The association of D-dimer with a history of stroke suggests that coagulation activation may contribute to the pathophysiology of stroke in clinically severe forms of SCD. More research is needed to evaluate the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/mtd4-5f55Test; https://cdr.lib.unc.edu/downloads/qb98mp65h?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/qb98mp65hTest |
| DOI: | 10.17615/mtd4-5f55 |
| الإتاحة: | https://doi.org/10.17615/mtd4-5f55Test https://cdr.lib.unc.edu/downloads/qb98mp65h?file=thumbnailTest https://cdr.lib.unc.edu/downloads/qb98mp65hTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.C89C8EF3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/mtd4-5f55 |
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