دورية أكاديمية
Oxidant stress in Neisseria gonorrhoeae: adaptation and effects on L-(+)-lactate dehydrogenase activity.
| العنوان: | Oxidant stress in Neisseria gonorrhoeae: adaptation and effects on L-(+)-lactate dehydrogenase activity. |
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| المؤلفون: | Fu, Kai-Song, Hassett, Daniel J., Cohen, Myron S. |
| المصدر: | Infection and Immunity, 57(7) |
| سنة النشر: | 1989 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Hiperóxido, Neisseria gonorrhoeae, Résistance, Hydrogen Peroxides, Enzyme, Neisseriaceae, Enzymatic activity, Adaptation, Bacteria, Hyperoxyde, Resistance, Hyperoxides, Milieu oxydant, Métabolisme, Bactérie, Oxidizing environment, Lactate dehydrogenase, Medio oxidante, Hydrogène Peroxyde, Metabolism, Activité enzymatique, Micrococcales |
| الوصف: | Neisseria gonorrhoeae, an obligate human pathogen, is subjected to oxidant stress when attacked by 02 reduction products formed by neutrophils. In this study, exposure of gonococci to sublethal concentrations of superoxide and hydrogen peroxide (and related 0-centered radicals) resulted in phenotypic resistance to oxidant stress. Adaptation required new protein formation but was not related to increases in superoxide dismutase or catalase. We have previously demonstrated that gonococci use phagocyte-derived L-(+)-lactate. Oxidant stress of greater magnitude than that required for adaptation led to a generalized increase in bacterial metabolism, particularly in L-(+)- and D-(-)-lactate utilization and lactate dehydrogenase activity. Increased lactate utilization required new protein synthesis. These results suggest the possibility that lactate metabolism is of importance to N. gonorrhoeae subjected to oxidant stress. Use of Ict mutant organisms unable to use L-(+)-lactate should allow examination of this hypothesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/yedf-7j94Test; https://cdr.lib.unc.edu/downloads/cf95jj972?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/cf95jj972Test |
| DOI: | 10.17615/yedf-7j94 |
| الإتاحة: | https://doi.org/10.17615/yedf-7j94Test https://cdr.lib.unc.edu/downloads/cf95jj972?file=thumbnailTest https://cdr.lib.unc.edu/downloads/cf95jj972Test |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.45EEBBC1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/yedf-7j94 |
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