دورية أكاديمية
Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer
| العنوان: | Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer |
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| المؤلفون: | Zhao, Di, Zou, Shao Wu, Liu, Ying, Zhou, Xin, Mo, Yan, Wang, Ping, Xu, Yan Hui, Dong, Bo, Xiong, Yue, Lei, Qun Ying, Guan, Kun Liang |
| المصدر: | Cancer Cell, 23(4) |
| سنة النشر: | 2013 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Cell Movement, Down-Regulation, Cell Growth Processes, Autophagy, Lysine, Animals, Isoenzymes, Mice, Humans, Pancreatic Neoplasms, L-Lactate Dehydrogenase, Acetylation, Nude, HeLa Cells, Gene Knockdown Techniques |
| الوصف: | Tumor cells commonly have increased glucose uptake and lactate accumulation. Lactate is produced from pyruvate by lactate dehydrogenase A (LDH-A), which is frequently overexpressed in tumor cells and is important for cell growth. Elevated transcription by c-Myc or HIF1α may contribute to increased LDH-A in some cancer types. Here, we show that LDH-A is acetylated at lysine 5 (K5) and that this acetylation inhibits LDH-A activity. Furthermore, the K5-acetylated LDH-A is recognized by the HSC70 chaperone and delivered to lysosomes for degradation. Replacement of endogenous LDH-A with an acetylation mimetic mutant decreases cell proliferation and migration. Importantly, K5 acetylation of LDH-A is reduced in human pancreatic cancers. Our study reveals a mechanism of LDH-A upregulation in pancreatic cancers. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/2c4r-f408Test; https://cdr.lib.unc.edu/downloads/fq9781567?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/fq9781567Test |
| DOI: | 10.17615/2c4r-f408 |
| الإتاحة: | https://doi.org/10.17615/2c4r-f408Test https://cdr.lib.unc.edu/downloads/fq9781567?file=thumbnailTest https://cdr.lib.unc.edu/downloads/fq9781567Test |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.44E3438 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/2c4r-f408 |
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