التفاصيل البيبلوغرافية
العنوان: |
Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes |
المؤلفون: |
Berndt, S.I., Vijai, J., Benavente, Y., Camp, N.J., Nieters, A., Wang, Z., Smedby, K.E., Kleinstern, G., Hjalgrim, H., Besson, C., Skibola, C.F., Morton, L.M., Brooks-Wilson, A.R., Teras, L.R., Breeze, C., Arias, J., Adami, H.-O., Albanes, D., Anderson, K.C., Ansell, S.M., Bassig, B., Becker, N., Bhatti, P., Birmann, B.M., Boffetta, P., Bracci, P.M., Brennan, P., Brown, E.E., Burdett, L., Cannon-Albright, L.A., Chang, E.T., Chiu, B.C.H., Chung, C.C., Clavel, J., Cocco, P., Colditz, G., Conde, L., Conti, D.V., Cox, D.G., Curtin, K., Casabonne, D., De Vivo, I., Diver, W.R., Dogan, A., Edlund, C.K., Foretova, L., Fraumeni, J.F., Jr, Gabbas, A., Ghesquières, H., Giles, G.G., Glaser, S., Glenn, M., Glimelius, B., Gu, J., Habermann, T.M., Haiman, C.A., Haioun, C., Hofmann, J.N., Holford, T.R., Holly, E.A., Hutchinson, A., Izhar, A., Jackson, R.D., Jarrett, R.F., Kaaks, R., Kane, E., Kolonel, L.N., Kong, Y., Kraft, P., Kricker, A., Lake, A., Lan, Q., Lawrence, C., Li, D., Liebow, M., Link, B.K, Magnani, C., Maynadie, M., McKay, J., Melbye, M., Miligi, L., Milne, R.L., Molina, T.J., Monnereau, A., Montalvan, R., North, K.E., Novak, A.J., Onel, K., Purdue, M.P., Rand, K.A., Riboli, E., Riby, J., Roman, E., Salles, G., Sborov, D.W., Severson, R.K., Shanafelt, T.D., Smith, M.T., Smith, A., Song, K.W., Song, L., Southey, M.C., Spinelli, J.J., Staines, A., Stephens, D., Sutherland, H.J., Tkachuk, K., Thompson, C.A., Tilly, H., Tinker, L.F., Travis, R.C., Turner, J., Vachon, C.M., Vajdic, C.M., Van Den Berg, A., Van Den Berg, D.J., Vermeulen, R.C.H., Vineis, P., Wang, S.S., Weiderpass, E., Weiner, G.J., Weinstein, S., Doo, N.W., Ye, Y., Yeager, M., Yu, K., Zeleniuch-Jacquotte, A., Zhang, Y., Zheng, T., Ziv, E., Sampson, J., Chatterjee, N., Offit, K., Cozen, W., Wu, X., Cerhan, J.R., Chanock, S.J., Slager, S.L., Rothman, N. |
المصدر: |
Leukemia, 36(12) |
بيانات النشر: |
Springer Nature |
سنة النشر: |
2022 |
المجموعة: |
Carolina Digital Repository (UNC - University of North Carolina) |
مصطلحات موضوعية: |
diffuse large B cell lymphoma, gene locus, multiple myeloma, genetic susceptibility, nonhodgkin lymphoma, genetic risk score, controlled study, genome-wide association study, Risk Factors, marginal zone lymphoma, major clinical study, risk factor, germ cell, heritability, single nucleotide polymorphism, carcinogenesis, genotyping, Germ Cells, Article, Case-Control Studies, genetic correlation, chronic lymphatic leukemia, follicular lymphoma, Humans, Hodgkin disease, cancer classification, Polymorphism, Single Nucleotide, case control study, Genetic Predisposition to Disease |
الوصف: |
Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture. |
نوع الوثيقة: |
article in journal/newspaper |
اللغة: |
English |
العلاقة: |
https://doi.org/10.17615/1b8m-w521Test; https://cdr.lib.unc.edu/downloads/q237j350q?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/q237j350qTest |
DOI: |
10.17615/1b8m-w521 |
الإتاحة: |
https://doi.org/10.17615/1b8m-w521Test https://cdr.lib.unc.edu/downloads/q237j350q?file=thumbnailTest https://cdr.lib.unc.edu/downloads/q237j350qTest |
رقم الانضمام: |
edsbas.1B49F2CF |
قاعدة البيانات: |
BASE |