التفاصيل البيبلوغرافية
| العنوان: |
Basic design and simulation of a SPECT microscope for in vivo stem cell imaging |
| المؤلفون: |
Moats, Rex A., Tang, Yang, Hugg, James W., Meier, Dirk, Koos, David S., Hartsough, Neal E., Patt, Bradley E., Wagenaar, Douglas J. |
| المساهمون: |
Pelc, Norbert J., Samei, Ehsan, Nishikawa, Robert M. |
| المصدر: |
Medical Imaging 2011: Physics of Medical Imaging, Lake Buena Vista, FL, February 13-17, 2011 |
| بيانات النشر: |
Society of Photo-Optical Instrumentation Engineers |
| سنة النشر: |
2011 |
| المجموعة: |
Caltech Authors (California Institute of Technology) |
| الوصف: |
The need to understand the behavior of individual stem cells at the various stages of their differentiation and to assess the resulting reparative action in pre-clinical model systems, which typically involves laboratory animals, provides the motivation for imaging of stem cells in vivo at high resolution. Our initial focus is to image cells and cellular events at single cell resolution in vivo in shallow tissues (few mm of intervening tissue) in laboratory mice and rates. In order to accomplish this goal we are building a SPECT-based microscope. We based our design on earlier theoretical work with near-field coded apertures and have adjusted the components of the system to meet the real-world demands of instrument construction and of animal imaging. Our instrumental design possesses a reasonable trade-off between field-of-view, sensitivity, and contrast performance (photon penetration). A layered gold aperture containing 100 pinholes and intended for use in coded aperture imaging application has been designed and constructed. A silicon detector connected to a TimePix readout from the CERN collaborative group was selected for use in our prototype microscope because of its ultra-high spatial and energy resolution capabilities. The combination of the source, aperture, and detector has been modeled and the coded aperture reconstruction of simulated sources is presented in this work. ; © 2011 SPIE. We would like to thank Dan Gazit, Gadi Pelled, Todd Peterson, Gunnar Maehlum, William Barber, and Roberto Accorsi. Funding from the California Institute for Regenerative Medicine (CIRM), Tools & Technologies I program, grant RT01-01027 is gratefully acknowledged. ; Published - 79614B_1.pdf |
| نوع الوثيقة: |
book part |
| اللغة: |
unknown |
| العلاقة: |
https://doi.org/10.1117/12.878427Test; oai:authors.library.caltech.edu:j4mfq-n7t49; eprintid:71584; resolverid:CaltechAUTHORS:20161028-135256492 |
| DOI: |
10.1117/12.878427 |
| الإتاحة: |
https://doi.org/10.1117/12.878427Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; Other |
| رقم الانضمام: |
edsbas.ACF20A9F |
| قاعدة البيانات: |
BASE |
