التفاصيل البيبلوغرافية
| العنوان: |
Small molecule somatostatin receptor subtype-2 antagonists |
| المؤلفون: |
Hay, Bruce A., Cole, Bridget M., DiCapua, Frank, Kirk, Glen W., Murray, Marianne C., Nardone, Rona A., Pelletier, Dennis J., Ricketts, Anthony P., Robertson, Alan S., Siegel, Todd W. |
| المصدر: |
Bioorganic and Medicinal Chemistry Letters, 11(20), 2731-2734, (2001-10-22) |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2001 |
| المجموعة: |
Caltech Authors (California Institute of Technology) |
| الوصف: |
The first potent small molecule sst2 antagonists are reported. Altering known sst2 agonist molecules yielded compounds with high sst2 binding affinity and full antagonist activity. Compound 7a, for example, displaced somatostatin binding to the sst2 receptor with an IC₅₀=2.9 nM and antagonized somatostatin action with an IC₅₀=29 nM. ; © 2001 Elsevier Science Ltd. Received 1 June 2001, Accepted 3 August 2001, Available online 3 September 2001. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://doi.org/10.1016/s0960-894xTest(01)00568-6; oai:authors.library.caltech.edu:x6fjb-w5946; eprintid:103008; resolverid:CaltechAUTHORS:20200505-151220694 |
| DOI: |
10.1016/s0960-894x(01)00568-6 |
| الإتاحة: |
https://doi.org/10.1016/s0960-894xTest(01)00568-6 |
| حقوق: |
info:eu-repo/semantics/closedAccess ; Other |
| رقم الانضمام: |
edsbas.F2559413 |
| قاعدة البيانات: |
BASE |
