دورية أكاديمية
Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms
| العنوان: | Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms |
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| المؤلفون: | Livanos, Alexandra E., Jha, Divya, Cossarini, Francesca, Gonzalez-Reiche, Ana S., Tokuyama, Minami, Aydillo, Teresa, Parigi, Tommaso L., Ladinsky, Mark S., Ramos, Irene, Dunleavy, Katie, Lee, Brian, Dixon, Rebekah E., Chen, Steven T., Martinez-Delgado, Gustavo, Nagula, Satish, Bruce, Emily A., Ko, Huaibin M., Glicksberg, Benjamin S., Nadkarni, Girish, Pujadas, Elisabet, Reidy, Jason, Naymagon, Steven, Grinspan, Ari, Ahmad, Jawad, Tankelevich, Michael, Bram, Yaron, Gordon, Ronald, Sharma, Keshav, Houldsworth, Jane, Britton, Graham J., Chen-Liaw, Alice, Spindler, Matthew P., Plitt, Tamar, Wang, Pei, Cerutti, Andrea, Faith, Jeremiah J., Colombel, Jean-Frederic, Kenigsberg, Ephraim, Argmann, Carmen, Merad, Miriam, Gnjatic, Sacha, Harpaz, Noam, Danese, Silvio, Cordon-Cardo, Carlos, Rahman, Adeeb, Schwartz, Robert E., Kumta, Nikhil A., Aghemo, Alessio, Bjorkman, Pamela J., Petralia, Francesca, van Bakel, Harm, Garcia-Sastre, Adolfo, Mehandru, Saurabh |
| المصدر: | Gastroenterology, 160(7), 2435-2450, (2021-06) |
| بيانات النشر: | AGA Institute |
| سنة النشر: | 2021 |
| المجموعة: | Caltech Authors (California Institute of Technology) |
| مصطلحات موضوعية: | COVID-19, SARS-CoV-2, GI symptoms, GI infection, outcomes, host immune response |
| الوصف: | Background & Aims: Given that gastrointestinal (GI) symptoms are a prominent extrapulmonary manifestation of COVID-19, we investigated intestinal infection with SARS-CoV-2, its effect on pathogenesis, and clinical significance. Methods: Human intestinal biopsy tissues were obtained from patients with COVID-19 (n = 19) and uninfected control individuals (n = 10) for microscopic examination, cytometry by time of flight analyses, and RNA sequencing. Additionally, disease severity and mortality were examined in patients with and without GI symptoms in 2 large, independent cohorts of hospitalized patients in the United States (N = 634) and Europe (N = 287) using multivariate logistic regressions. Results: COVID-19 case patients and control individuals in the biopsy cohort were comparable for age, sex, rates of hospitalization, and relevant comorbid conditions. SARS-CoV-2 was detected in small intestinal epithelial cells by immunofluorescence staining or electron microscopy in 15 of 17 patients studied. High-dimensional analyses of GI tissues showed low levels of inflammation, including down-regulation of key inflammatory genes including IFNG, CXCL8, CXCL2, and IL1B and reduced frequencies of proinflammatory dendritic cells compared with control individuals. Consistent with these findings, we found a significant reduction in disease severity and mortality in patients presenting with GI symptoms that was independent of sex, age, and comorbid illnesses and despite similar nasopharyngeal SARS-CoV-2 viral loads. Furthermore, there was reduced levels of key inflammatory proteins in circulation in patients with GI symptoms. Conclusions: These data highlight the absence of a proinflammatory response in the GI tract despite detection of SARS-CoV-2. In parallel, reduced mortality in patients with COVID-19 presenting with GI symptoms was observed. A potential role of the GI tract in attenuating SARS-CoV-2–associated inflammation needs to be further examined. ; © 2021 by the AGA Institute. Received 20 November 2020, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://doi.org/10.1053/j.gastro.2021.02.056Test; oai:authors.library.caltech.edu:tcca5-cff90; https://www.ncbi.nlm.nih.gov/pmc/PMC7931673Test; eprintid:108318; resolverid:CaltechAUTHORS:20210305-070228450 |
| DOI: | 10.1053/j.gastro.2021.02.056 |
| الإتاحة: | https://doi.org/10.1053/j.gastro.2021.02.056Test https://www.ncbi.nlm.nih.gov/pmc/PMC7931673Test |
| حقوق: | info:eu-repo/semantics/openAccess ; Other |
| رقم الانضمام: | edsbas.2108E603 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1053/j.gastro.2021.02.056 |
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