التفاصيل البيبلوغرافية
| العنوان: |
Cadherins and synaptic plasticity |
| المؤلفون: |
Tai, Chin-Yin, Kim, Sally A., Schuman, Erin M. |
| المصدر: |
Current Opinion in Cell Biology, 20(5), 567-575, (2008-10) |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2008 |
| المجموعة: |
Caltech Authors (California Institute of Technology) |
| مصطلحات موضوعية: |
CELL-ADHESION MOLECULES, AMPA RECEPTOR TRAFFICKING, N-CADHERIN, BETA-CATENIN, TERM PLASTICITY, BINDING PROTEIN, CLEAVAGE, CALCIUM, FAMILY, POTENTIATION |
| الوصف: |
Given their trans-synaptic localization, their persistent expression at mature synapses and their distinct biochemical and adhesive properties, cadherins are uniquely poised at the synapse to mediate synaptic plasticity, the ability to change synaptic function thought to underlie learning and memory. For example recent work suggests that cadherins may recruit and stabilize AMPA receptors at the synapse via direct interactions or through complex formation, revealing cross talk between postsynaptic signaling and adhesion. Moreover, the use of small interfering RNA knockdown of cadherin, the availability of N-cadherin-deficient embryonic stem cells and the acute disruption of cadherin function with peptide application in vivo have allowed for more precise dissection of the molecular mechanisms by which cadherins function in both structural and functional plasticity. ; © 2008 Published by Elsevier Ltd. Available online 19 July 2008. We thank Bruce Tai and Anh Pham for helpful comments on the manuscript. Work in our laboratory for this work is supported by the National Institutes of Health (MH076910-01) and the Damon Runyon Foundation. E.M.S. is an investigator of the Howard Hughes Medical Institute. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://doi.org/10.1016/j.ceb.2008.06.003Test; oai:authors.library.caltech.edu:bbfjx-hj684; eprintid:13523; resolverid:CaltechAUTHORS:TAIcob08 |
| DOI: |
10.1016/j.ceb.2008.06.003 |
| الإتاحة: |
https://doi.org/10.1016/j.ceb.2008.06.003Test |
| حقوق: |
info:eu-repo/semantics/closedAccess ; Other |
| رقم الانضمام: |
edsbas.F5649B54 |
| قاعدة البيانات: |
BASE |
