دورية أكاديمية
Epidemiology of invasive group B streptococcal disease in infants from urban area of South China, 2011–2014
| العنوان: | Epidemiology of invasive group B streptococcal disease in infants from urban area of South China, 2011–2014 |
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| المؤلفون: | Guan, X., Mu, X., Ji, W., Yuan, C., He, P., Zhang, L., Huang, Y., Li, J., Chen, J., Zhong, H., Pang, S., Tan, N., Deng, Q., Gao, K., Chang, Chien-Yi, Liu, H. |
| سنة النشر: | 2018 |
| المجموعة: | Bradford Scholars@University of Bradford |
| مصطلحات موضوعية: | Infants, Group B Streptococcus, Neonatal infections, Serotype, Multilocus sequence type (MLST), Antimicrobial resistance |
| الوصف: | Yes ; Background: Group B Streptococcus (GBS) is a leading cause of morbidity and mortality in infants in both developed and developing countries. To our knowledge, only a few studies have been reported the clinical features, treatment and outcomes of the GBS disease in China. The severity of neonatal GBS disease in China remains unclear. Population-based surveillance in China is therefore required. Methods: We retrospectively collected data of <3 months old infants with culture-positive GBS in sterile samples from three large urban tertiary hospitals in South China from Jan 2011 to Dec 2014. The GBS isolates and their antibiotic susceptibility were routinely identified in clinical laboratories in participating hospitals. Serotyping and multi-locus sequence typing (MLST) were also conducted for further analysis of the neonatal GBS disease. Results: Total 70 cases of culture-confirmed invasive GBS infection were identified from 127,206 live births born in studying hospitals, giving an overall incidence of 0.55 per 1000 live births (95% confidence interval [CI] 0.44–0.69). They consisted of 49 with early-onset disease (EOD, 0.39 per 1000 live births (95% CI 0.29–0.51)) and 21 with late-onset disease (LOD, 0.17 per 1000 live births (95% CI 0.11–0.25)). The incidence of EOD increased significantly over the studying period. Five infants (4 EOD and 1 LOD) died before discharge giving a mortality rate of 7.1% and five infants (7.1%, 2 EOD and 3 LOD) had neurological sequelae. Within 68 GBS isolates from GBS cases who born in the studying hospitals or elsewhere, serotype III accounted for 77.9%, followed by Ib (14.7%), V (4.4%), and Ia (2.9%). MLST analysis revealed the presence of 13 different sequence types among the 68 GBS isolates and ST-17 was the most frequent sequence type (63.2%). All isolates were susceptible to penicillin, ceftriaxone, vancomycin and linezolid, while 57.4% and 51.5% were resistant to erythromycin and clindamycin, respectively. Conclusions: This study gains the insight into the spectrum of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://hdl.handle.net/10454/15101Test; https://doi.org/10.1186/s12879-017-2811-0Test |
| DOI: | 10.1186/s12879-017-2811-0 |
| الإتاحة: | https://doi.org/10.1186/s12879-017-2811-0Test http://hdl.handle.net/10454/15101Test |
| حقوق: | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0Test/) applies to the data made available in this article, unless otherwise stated. |
| رقم الانضمام: | edsbas.A603360C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12879-017-2811-0 |
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