دورية أكاديمية
Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use
| العنوان: | Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use |
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| المؤلفون: | Badran, Saif, Doi, Suhail, Hammouda, Atalla, Musa, Omran, Habib, Abdella |
| المصدر: | Biomolecules and Biomedicine; Vol. 23 No. 5 (2023); 914–919 ; 2831-090X ; 2831-0896 |
| بيانات النشر: | Association of Basic Medical Sciences of FBIH |
| سنة النشر: | 2023 |
| المجموعة: | Bosnian Journal of Basic Medical Sciences (BJBMS) |
| مصطلحات موضوعية: | Diabetes mellitus, oral glucose tolerance test (GTT), weighted average glucose, Doi’s weighted average glucose (dwAG), under the curve, homeostatic model assessment for insulin sensitivity (HOMA-S) |
| الوصف: | In this study, we examined the performance of a novel index of glucose excursion (Doi’s weighted average glucose [dwAG]) in relation to the conventional measure of area under the oral glucose tolerance test (A-GTT) and the homeostatic model assessment for insulin sensitivity (HOMA-S) and pancreatic beta cell function (HOMA-B). A cross-sectional comparison of the new index was conducted using 66 oral glucose tolerance tests (GTTs) performed at different follow-up times among 27 participants who had undergone surgical subcutaneous fat removal (SSFR). Comparisons across categories were made using box plots and the Kruskal-Wallis one-way ANOVA on ranks. Passing-Bablok regression was used to compare the dwAG against the conventional A-GTT. The Passing-Bablok regression model suggested a cutoff for normality for the A-GTT of 15.14 mmol/L·2h-1 compared to the dwAG’s suggested threshold of 6.8 mmol/L. For every 1 mmol/L·2h-1 increase in A-GTT, the dwAG value increased by 0.473 mmol/L. The glucose area under the curve correlated well with the four defined dwAG categories, with at least one of the categories having a different median A-GTT value (KW Chi2 = 52.8 [df = 3], P < 0.001). The HOMA-S tertiles were also associated with significantly different levels of glucose excursion measured through both the dwAG value (KW Chi2 = 11.4 [df = 2], P = 0.003) and A-GTT measure (KW Chi2 = 13.1 [df = 2], P = 0.001). It is concluded that the dwAG value and categories serve as a simple and accurate tool that can be used for interpreting glucose homeostasis across clinical settings. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/xml; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/8807/2905Test; https://www.bjbms.org/ojs/index.php/bjbms/article/view/8807/2742Test; https://www.bjbms.org/ojs/index.php/bjbms/article/view/8807Test |
| DOI: | 10.17305/bb.2022.8807 |
| الإتاحة: | https://doi.org/10.17305/bb.2022.8807Test https://www.bjbms.org/ojs/index.php/bjbms/article/view/8807Test |
| حقوق: | Copyright (c) 2023 Saif Badran, Suhail A. Doi, Atalla Hammouda, Omran A. H. Musa, Abdella M. Habib ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.D673CD1D |
| قاعدة البيانات: | BASE |
| DOI: | 10.17305/bb.2022.8807 |
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