دورية أكاديمية
NRGN, S100B and GFAP levels are significantly increased in patients with structural lesions resulting from mild traumatic brain injuries
| العنوان: | NRGN, S100B and GFAP levels are significantly increased in patients with structural lesions resulting from mild traumatic brain injuries |
|---|---|
| المؤلفون: | Çevik, Serdar, Özgenç, Mustafa Murat, Güneyi, Ahmet, Evran, Şevket, Çalış, Fatih, Katar, Salim, Soyalp, Celaleddin, Hanımoğlu, Hakan, Kaynar, Mehmet Yaşar |
| المساهمون: | Tıp Fakültesi |
| بيانات النشر: | Elsevier B.V. |
| سنة النشر: | 2019 |
| المجموعة: | Biruni University Institutional Repository (DSpace@Biruni) |
| مصطلحات موضوعية: | Traumatic Brain Injury, Computed Tomography, Glial Fibrillary Acidic Protein, Biomarkers, Neurogranin, Calcium-Binding Protein S100 Beta |
| الوصف: | Objective: To determine whether serum neurogranin (NRGN), glial fibrillary acidic protein (GFAP), and calciumbinding protein S100 beta (S100B) levels are associated with traumatic intracranial lesions compared to computed tomography (CT) findings of patients with mild traumatic brain injury (mTBI). Patients and Methods: The cross-sectional study cohort included 48 patients who were admitted to the Emergency Department with a complaint of mTBI, a Glasgow Coma Scale score of 14–15, and at least one symptom of head trauma (i.e., post-traumatic amnesia, nausea or vomiting, post-traumatic seizures, persistent headache, and transient loss of consciousness). Blood samples and CT scans were obtained for all patients within 4 h of injury. Age-matched patients without intracranial traumatic pathology (CT-) were recruited as a control group. Blood samples were measured for NRGN, GFAP, and S100B levels. Results: Of 48 patients, 24 were CT + and had significantly higher serum NRGN (5.79 vs. 2.95 ng/mL), GFAP (0.59 vs.0.36 ng/mL), and S100B (1.72 vs.0.73 μg/L) levels than those who were CT- (p = 0.001, p = 0.026, and p < 0.001, respectively). ROC curves showed that NRGN, GFAP, and S100B levels were sufficient to distinguish traumatic brain injury in patients with mTBI. At the cut-off value for NRGN of 1.87 ng/mL, sensivity was 83.3%, and specificity was 58.3%. At the cut-off value for GFAP of 0.23 ng/mL, sensivity was 75% and specificity was 62.5%. The optimal cut-off value for S100B was 0.47 μg/L (95.8% sensitivity and 62.5% specificity). Conclusion: This is the first study to evaluate NRGN in human serum after mTBI. We confirmed that NRGN levels were significantly higher in CT + patients than CT- patients in the mTBI patient population. Future studies of larger populations and different age groups (especially pediatric) can help reduce the number of CT scans as a reliable and noninvasive diagnostic tool for evaluating NRGN protein levels in mTBI patients with a low probability of intracranial lesions. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0303-8467 1872-6968 |
| العلاقة: | https://doi.org/10.1016/j.clineuro.2019.105380Test; Clinical Neurology and Neurosurgery; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.12445/1124Test; 183 |
| DOI: | 10.1016/j.clineuro.2019.105380 |
| الإتاحة: | https://doi.org/20.500.12445/1124Test https://doi.org/10.1016/j.clineuro.2019.105380Test https://hdl.handle.net/20.500.12445/1124Test |
| حقوق: | info:eu-repo/semantics/embargoedAccess ; Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/usTest/ |
| رقم الانضمام: | edsbas.693C8DFE |
| قاعدة البيانات: | BASE |
| تدمد: | 03038467 18726968 |
|---|---|
| DOI: | 10.1016/j.clineuro.2019.105380 |