دورية أكاديمية

Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†

التفاصيل البيبلوغرافية
العنوان: Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†
المؤلفون: Yahui Zhang, Yi Lin, Guoqiang Li, Yuan Yuan, Xuejiao Wang, Na Li, Chuanhao Xiong, Yueying Yang, Yuhang Ma, Zhijian Zhang, Xiaoying Ding
المساهمون: Yahui Zhang, Yi Lin, Guoqiang Li, Yuan Yuan, Xuejiao Wang, Na Li, Chuanhao Xiong, Yueying Yang, Yuhang Ma, Zhijian Zhang, Xiaoying Ding
المصدر: https://doi.org/10.1093/biolre/ioad032Test.
بيانات النشر: Society for the Study of Reproduction
سنة النشر: 2023
المجموعة: BioOne Online Journals
مصطلحات موضوعية: browning, GLP-1 receptor agonists (GLP-1RAs), hyperandrogenemia, polycystic ovary syndrome (PCOS)
جغرافية الموضوع: world
الوصف: Polycystic ovary syndrome is a complicated hormonal and metabolic disorder. The exact pathogenesis of polycystic ovary syndrome is not clear thus far. Inflammation is involved in the progression of polycystic ovary syndrome. In addition, brown adipose tissue activity is impaired in polycystic ovary syndrome. Interestingly, glucagon-like peptide-1 receptor agonists have been reported to alleviate inflammation and promote browning of white adipose tissue. In this study, the effects of glucagon-like peptide-1 receptor agonists on polycystic ovary syndrome mice were explored. Mice were randomly assigned into four groups: control, dehydroepiandrosterone, dehydroepiandrosterone + liraglutide, and dehydroepiandrosterone + semaglutide. Relative indexes were measured after glucagon-like peptide-1 receptor agonist intervention. Glucose metabolism in polycystic ovary syndrome mice was ameliorated by glucagon-like peptide-1 receptor agonists, while the reproductive endocrine disorder of polycystic ovary syndrome mice was partially reversed. The messenger ribonucleic acid levels of steroidogenic enzymes and the expression of inflammatory mediators in serum and ovaries of polycystic ovary syndrome mice were improved. Furthermore, toll-like receptor 4 and phosphorylation of nuclear factor-kappa B protein levels were decreased by glucagon-like peptide-1 receptor agonists in ovary. Notably, after glucagon-like peptide-1 receptor agonist intervention, the expression of brown adipose tissue marker levels was considerably raised in the white adipose tissue of polycystic ovary syndrome mice. In conclusion, the hyperinsulinemia and hyperandrogenemia of polycystic ovary syndrome mice were alleviated by glucagon-like peptide-1 receptor agonist intervention, which was associated with mitigating inflammation and stimulating adipose tissue browning. Summary Sentence GLP-1RAs could improve the symptoms of polycystic ovary mice. Graphical Abstract
نوع الوثيقة: text
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اللغة: English
DOI: 10.1093/biolre/ioad032
الإتاحة: https://doi.org/10.1093/biolre/ioad032Test
حقوق: All rights reserved.
رقم الانضمام: edsbas.BF7BCA74
قاعدة البيانات: BASE