التفاصيل البيبلوغرافية
| العنوان: |
Inclusion complexes of trihexyphenidyl with natural and modified cyclodextrins |
| المؤلفون: |
Maeda, Hideko, Tanaka, Risa, Nakayama, Hirokazu |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2015 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Trihexyphenidyl, Sulfobutylether-β-cyclodextrin, Inclusion complexes, Spectrofluorometry, Solubility |
| الوصف: |
The solubility of trihexyphenidyl (Thp) was improved by its combination with β -cyclodextrin ( β− CD) and modified β -CDs. The solubility of Thp was found to be increased in the presence of β -CD, hydroxypropyl- β -cyclodextrin (HP- β -CD), methyl- β -cyclodextrin (Me- β -CD) and sulfobutylether- β -cyclodextrin (SBE- β -CD). In particular, the solubility of Thp in conjunction with SBE- β -CD was increased by a factor of 11. The formation constant ( K c ) for the Thp/SBE- β -CD inclusion complex was determined to be 2300 L/mol based on fluorometry data. The structure of the Thp/SBE- β -CD complex in aqueous solution was examined by 1 H- 1 H rotating frame nuclear Overhauser effect spectroscopy (ROESY) NMR, and the phenyl moiety of the Thp was found to coordinate with the secondary hydroxyl face of the SBE- β -CD. A solid Thp/SBE- β -CD inclusion complex was prepared by freeze-drying. |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
http://www.springerplus.com/content/4/1/218Test |
| الإتاحة: |
http://www.springerplus.com/content/4/1/218Test |
| حقوق: |
Copyright 2015 Maeda et al.; licensee Springer. |
| رقم الانضمام: |
edsbas.563E5AAD |
| قاعدة البيانات: |
BASE |
