التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers |
| المؤلفون: |
Tripodi, Dominique, Brunet-Courtois, Benedicte, Nael, Virginie, Audrain, Marie, Chailleux, Edmond, Germaud, Patrick, Naudin, Frederique, Muller, Jean-Yves, Bourrut-Lacouture, Martine, Durand-Perdriel, Marie-Henriette, Gordeeff, Claire, Guillaumin, Guyonne, Houdebine, Marietherese, Raffi, Francois, Boutoille, David, Biron, Charlotte, Potel, Gilles, Roedlich, Claude, Geraut, Christian, Schablon, Anja, Nienhaus, Albert |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2009 |
| المجموعة: |
BioMed Central |
| الوصف: |
Introduction Using French cut-offs for the Tuberculin Skin Test (TST), results of the TST were compared with the results of an Interferon-γ Release Assay (IGRA) in Healthcare Workers (HCW) after contact to AFB-positive TB patients. Methods Between May 2006 and May 2007, a total of 148 HCWs of the University Hospital in Nantes, France were tested simultaneously with IGRA und TST. A TST was considered to indicate recent latent TB infection (LTBI) if an increase of >10 mm or if TST ≥ 15 mm for those with no previous TST result was observed. For those with a positive TST, chest X-ray was performed and preventive chemotherapy was offered. Results All HCWs were BCG-vaccinated. The IGRA was positive in 18.9% and TST ≥ 10 mm was observed in 65.5%. A recent LTBI was believed to be highly probable in 30.4% following TST. Agreement between IGRA and TST was low (kappa 0.041). In 10 (16.7%) out of 60 HCWs who needed chest X-ray following TST the IGRA was positive. In 9 (20%) out of 45 HCWs to whom preventive chemotherapy was offered following TST the IGRA was positive. Of those considered TST-negative following the French guidelines, 20.5% were IGRA-positive. In a two-step strategy - positive TST verified by IGRA - 18 out of 28 (64.3%) IGRA-positive HCWs would not have been detected using French guidelines for TST interpretation. Conclusion The introduction of IGRA in contact tracings of BCG-vaccinated HCWs reduces X-rays and preventive chemotherapies. Increasing the cut-off for a positive TST does not seem to be helpful to overcome the effect of BCG vaccination on TST. |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
http://www.occup-med.com/content/4/1/30Test |
| الإتاحة: |
http://www.occup-med.com/content/4/1/30Test |
| حقوق: |
Copyright 2009 Tripodi et al; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.7C8FD901 |
| قاعدة البيانات: |
BASE |
