التفاصيل البيبلوغرافية
| العنوان: |
Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts |
| المؤلفون: |
Paulsen, Jonas, Sekelja, Monika, Oldenburg, Anja, Barateau, Alice, Briand, Nolwenn, Delbarre, Erwan, Shah, Akshay, Sørensen, Anita, Vigouroux, Corinne, Buendia, Brigitte, Collas, Philippe |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2017 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Three-dimensional (3D) genome, Hi-C, Lamin-associated domain (LAD), Laminopathy, Modeling, Nuclear lamin, Topologically-associated domain (TAD) |
| الوصف: |
Current three-dimensional (3D) genome modeling platforms are limited by their inability to account for radial placement of loci in the nucleus. We present Chrom3D, a user-friendly whole-genome 3D computational modeling framework that simulates positions of topologically-associated domains (TADs) relative to each other and to the nuclear periphery. Chrom3D integrates chromosome conformation capture (Hi-C) and lamin-associated domain (LAD) datasets to generate structure ensembles that recapitulate radial distributions of TADs detected in single cells. Chrom3D reveals unexpected spatial features of LAD regulation in cells from patients with a laminopathy-causing lamin mutation. Chrom3D is freely available on github. |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
English |
| العلاقة: |
http://genomebiology.com/2017/18/1/21Test |
| الإتاحة: |
http://genomebiology.com/2017/18/1/21Test |
| حقوق: |
Copyright 2017 The Author(s). |
| رقم الانضمام: |
edsbas.51605452 |
| قاعدة البيانات: |
BASE |
