التفاصيل البيبلوغرافية
| العنوان: |
Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis? |
| المؤلفون: |
Fernandez-Fernandez, Beatriz, Ortiz, Alberto, Gomez-Guerrero, Carmen, Barat, Antonio, Martín-Cleary, Catalina, Egido, Jesús |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2012 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Angiotensin, Juxtaglomerular apparatus hyperplasia, Nephrotic syndrome, Paricalcitol, Renin |
| الوصف: |
Background Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach. Our understanding on the molecular effects of dual blockade in humans is incomplete. Case presentation We present a patient with corticoid resistant nephrotic syndrome who developed marked juxtaglomerular apparatus hyperplasia and renin expression in the context of dual angiotensin system blockade. Conclusions Although renin may have profibrotic effects mediated by (pro)renin receptor activation, this report raises questions on the potential consequences of local renin activation on chronic kidney disease in patients with dual angiotensin blockade. |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
http://www.biomedcentral.com/1471-2369/13/21Test |
| الإتاحة: |
http://www.biomedcentral.com/1471-2369/13/21Test |
| حقوق: |
Copyright 2012 Fernandez-Fernandez et al.; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.4104DB53 |
| قاعدة البيانات: |
BASE |
