التفاصيل البيبلوغرافية
| العنوان: |
Role of the EGF+61A>G polymorphism in melanoma pathogenesis: an experience on a large series of Italian cases and controls |
| المؤلفون: |
Casula, Milena, Alaibac, Mauro, Pizzichetta, Maria A, Bono, Riccardo, Ascierto, Paolo A, Stanganelli, Ignazio, Canzanella, Sergio, Palomba, Grazia, Zattra, Edoardo, The Italian Melanoma Intergroup (IMI), Palmieri, Giuseppe |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2009 |
| المجموعة: |
BioMed Central |
| الوصف: |
Background A single nucleotide polymorphism (61A>G) in the epidermal growth factor ( EGF ) gene has been implicated in both melanoma pathogenesis and increased melanoma risk. To further evaluate this association, we conducted a case-control study in a clinic-based Italian population. Methods Individuals with less than 10 (N = 127) or more than 100 (N = 128) benign nevi, and patients with cutaneous melanoma (N = 418) were investigated for the EGF +61A>G polymorphism, using an automated sequencing approach. Results Overall, no difference in EGF genotype frequencies was observed among subjects with different number of nevi as well as when non-melanoma healthy controls were compared with the melanoma patients. However, a heterogeneous distribution of the frequencies of the G/G genotype was detected among cases and controls originating from North Italy (21.1 and 18.3%, respectively) vs. those from South Italy (12.6 and 17.1%, respectively). Conclusion Our findings further suggest that EGF +61A>G polymorphism may have a limited impact on predisposition and/or pathogenesis of melanoma and its prevalence may vary in different populations. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://www.biomedcentral.com/1471-5945/9/7Test |
| الإتاحة: |
http://www.biomedcentral.com/1471-5945/9/7Test |
| حقوق: |
Copyright 2009 Casula et al; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.C56D751D |
| قاعدة البيانات: |
BASE |
