التفاصيل البيبلوغرافية
| العنوان: |
Esophageal cancer risk by type of alcohol drinking and smoking: a case-control study in Spain |
| المؤلفون: |
Vioque, Jesus, Barber, Xavier, Bolumar, Francisco, Porta, Miquel, Santibáñez, Miguel, de la Hera, Manuela, Moreno-Osset, Eduardo, the PANESOES Study Group |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2008 |
| المجموعة: |
BioMed Central |
| الوصف: |
Background The effect of tobacco smoking and alcohol drinking on esophageal cancer (EC) has never been explored in Spain where black tobacco and wine consumptions are quite prevalent. We estimated the independent effect of different alcoholic beverages and type of tobacco smoking on the risk of EC and its main histological cell type (squamous cell carcinoma) in a hospital-based case-control study in a Mediterranean area of Spain. Methods We only included incident cases with histologically confirmed EC (n = 202). Controls were frequency-matched to cases by age, sex and province (n = 455). Information on risk factors was elicited by trained interviewers using structured questionnaires. Multiple logistic regression was used to estimate adjusted odds ratios and 95% confidence intervals (CI). Results Alcohol drinking and tobacco smoking were strong and independent risk factors for esophageal cancer. Alcohol was a potent risk factor with a clear dose-response relationship, particularly for esophageal squamous-cell cancer. Compared to never-drinkers, the risk for heaviest drinkers (≥ 75 g/day of pure ethanol) was 7.65 (95%CI, 3.16–18.49); and compared with never-smokers, the risk for heaviest smokers (≥ 30 cigarettes/day) was 5.07 (95%CI, 2.06–12.47). A low consumption of only wine and/or beer (1–24 g/d) did not increase the risk whereas a strong positive trend was observed for all types of alcoholic beverages that included any combination of hard liquors with beer and/or wine (p-trend<0.00001). A significant increase in EC risk was only observed for black-tobacco smoking (2.5-fold increase), not for blond tobacco. The effects for alcohol drinking were much stronger when the analysis was limited to the esophageal squamous cell carcinoma (n = 160), whereas a lack of effect for adenocarcinoma was evidenced. Smoking cessation showed a beneficial effect within ten years whereas drinking cessation did not. Conclusion Our study shows that the risk of EC, and particularly the squamous cell type, is strongly ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://www.biomedcentral.com/1471-2407/8/221Test |
| الإتاحة: |
http://www.biomedcentral.com/1471-2407/8/221Test |
| حقوق: |
Copyright 2008 Vioque et al; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.199962D0 |
| قاعدة البيانات: |
BASE |
