التفاصيل البيبلوغرافية
| العنوان: |
International cohort study of 73 anti-Ku-positive patients: association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysis |
| المؤلفون: |
Lakota, Katja, Thallinger, Gerhard G, Sodin-Semrl, Snezna, Rozman, Blaz, Ambrozic, Ales, Tomsic, Matija, Praprotnik, Sonja, Cucnik, Sasa, Mrak-Poljsak, Katjusa, Ceribelli, Angela, Cavazzana, Ilaria, Franceschini, Franco, Vencovsky, Jiri, Czirják, Laszlo, Varjú, Cecilia, Steiner, Gunther, Aringer, Martin, Stamenkovic, Bojana, Distler, Oliver, Matucci-Cerinic, Marco, Kveder, Tanja |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2012 |
| المجموعة: |
BioMed Central |
| الوصف: |
Introduction An international cohort study of 73 anti-Ku-positive patients with different connective tissue diseases was conducted to differentiate the anti-Ku-positive populations of patients based on their autoantibody profile and clinical signs/symptoms and to establish possible correlations between antibodies against Ku p70 and Ku p80 with autoimmune diseases. Methods Sera of anti-Ku-positive patients were collected from six European centers and were all secondarily tested (in the reference center); 73 were confirmed as positive. Anti-Ku antibodies were detected with counter-immunoelectrophoresis (CIE), line immunoassay (LIA), and immunoblot analyses. All clinical and laboratory data were follow-up cumulative data, except for anti-Ku antibodies. Statistical analyses were performed by using R (V 2.12.1). The Fisher Exact test was used to evaluate the association between anti-Ku antibodies and diagnosis, gender, clinical signs, and other observed antibodies. The P values were adjusted for multiple testing. Separation of disease populations based on the presence of antibodies and clinical signs was investigated by principal-components analysis, which was performed by using thr// R's prcomp function with standard parameters. Results A 16% higher prevalence of anti-Ku p70 was found over anti-Ku p80 antibodies. In 41 (57%) patients, a combination of both was detected. Five (7%) patients, who were CIE and/or LIA anti-Ku positive, were negative for both subsets, as detected with the immunoblot; 31% of the patients had undifferentiated connective tissue disease (UCTD); 29% had systemic sclerosis (SSc); 18% had systemic lupus erythematosus (SLE); 11% had rheumatoid arthritis; 7% had polymyositis; and 3% had Sjögren syndrome. Conclusions A significant positive association was found between female patients with anti-Ku p70 and joint/bone features, and a significant negative association was found between female patients with anti-Ku p80 only and joint/bone features ( P = 0.05, respectively). By using the first ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://arthritis-research.com/content/14/1/R2Test |
| الإتاحة: |
http://arthritis-research.com/content/14/1/R2Test |
| حقوق: |
Copyright 2012 Lakota et al.; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.BCFFE7B4 |
| قاعدة البيانات: |
BASE |
