التفاصيل البيبلوغرافية
| العنوان: |
Marked improvement in autoimmune pulmonary alveolar proteinosis with severe hypoxemia in a patient treated with ambroxol: a case report |
| المؤلفون: |
Oda, Nao, Tamai, Koji, Suzuki, Yujiro, Yoshimatsu, Harukazu, Matsuoka, Hirofumi, Matsumoto, Yusuke, Okada, Nobuhiko |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2015 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Autoimmune pulmonary alveolar proteinosis, Ambroxol, Severe hypoxemia |
| الوصف: |
Introduction Pulmonary alveolar proteinosis is characterized by accumulation of surfactant and phospholipids in the pulmonary alveoli. Whole lung lavage is considered the first-line therapy, which requires special techniques. To the best of our knowledge, there have only been limited reports that have demonstrated the effectiveness of ambroxol on a mild case of pulmonary alveolar proteinosis. Case presentation A 72-year-old Japanese woman presented to our hospital with a one-year history of productive cough and progressive dyspnea. Her chest computed tomography scan showed a bilateral crazy-paving pattern in both of her lungs. She was diagnosed with autoimmune pulmonary alveolar proteinosis based on bronchoalveolar lavage findings and the presence of serum anti-granulocyte macrophage colony-stimulating factor antibodies. She was severely hypoxemic, so we recommended whole lung lavage or inhaled granulocyte macrophage colony-stimulating factor treatment, which she refused. We initiated treatment with ambroxol and her symptoms markedly improved. Conclusions Although whole lung lavage is the first-line therapy for pulmonary alveolar proteinosis, oral ambroxol could be an alternative treatment option, even in patients with severe respiratory compromise. |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
http://www.jmedicalcasereports.com/content/9/1/100Test |
| الإتاحة: |
http://www.jmedicalcasereports.com/content/9/1/100Test |
| حقوق: |
Copyright 2015 Oda et al.; licensee BioMed Central. |
| رقم الانضمام: |
edsbas.35EC2BA3 |
| قاعدة البيانات: |
BASE |
