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1دورية أكاديمية
المؤلفون: Thiry, Nancy
المساهمون: De Laet, Chris, Hulstaert, Frank, Neyt, Mattias, Huybrechts, Michel, Cleemput, Irina
مصطلحات موضوعية: W 1 Serials. Periodicals, Journal Article, Peer Review, Great Britain, Adolescent, Adult, Belgium, Child, Cohort Studies, Cost-Benefit Analysis, Female, Humans, Health Care Costs, Markov Chains, Mass Screening, Papillomavirus Vaccines, Quality-Adjusted Life Years
الوصف: 161-170 ; OBJECTIVES: The cost-effectiveness of adding a human papillomavirus (HPV) vaccination program in 12-year-old females to the recommended cervical cancer screening in Belgium is examined. Moreover, the health and economic consequences of a potential decline in screening uptake after initiation of a HPV vaccination program are investigated. METHODS: A static Markov model is developed to estimate the direct effect of vaccination on precancerous lesions and cervical cancers. RESULTS: Vaccination is estimated to avoid 20 percent of the cervical cancers occurring in a 12-year-old girls' cohort and to cost 32,665 euro per quality-adjusted life-year (QALY) gained (95 percent credibility interval [CrI]: 17,447 euro to 68,078 euro), assuming a booster injection after 10 years, a limited duration of protection and discounting costs and effects at 3 percent and 1.5 percent, respectively. Assuming lifelong protection, HPV vaccination is estimated to cost 14,382 euro (95 percent CrI: 9,238 euro to 25,644 euro) per QALY gained, while avoiding 50 percent of the cervical cancer cases. In the base-case, a 10 percent reduction in screening compliance after vaccination obliterates the effect of vaccination on cervical cancer cases avoided, whereas further declines in the level of screening compliance even turned out to be detrimental for the cohort's health, inducing a mean loss in QALYs and life-year gained compared with the situation prevaccination. CONCLUSIONS: An HPV vaccination program should only be considered if the level of screening after vaccination can be maintained.
العلاقة: Vignette : https://kce.docressources.info/thumbnail.php?typeTest=1&id=2200; https://kce.docressources.info/index.php?lvl=notice_display&id=2200Test; 2200
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2دورية أكاديمية
المؤلفون: Peetermans, W.E.
المساهمون: Van de Vyver, N, Van Laethem, Y., Van Damme, Pierre, Thiry, Nancy, Trefois, P., Geerts, P., Schetgen, M., Peleman, R, Swennen, B., Verhaegen, J.
مصطلحات موضوعية: administration and dosage, Adult, Aged, Belgium, complications, Cost-Benefit Analysis, Economics, Humans, Journal Article, Peer Review, Pneumococcal Infections, Pneumococcal Vaccines, Practice Guideline [Publication type], prevention and control, Treatment outcome, W 1 Serials. Periodicals
الوصف: 329-337 ; A multidisciplinary expert panel, appointed by the High Council for Public Health, evaluated the scientific evidence on which the recommendations for the appropriate use of the pneumococcal vaccine was based and reviewed the studies that became available since previous reports. The conclusions of the working group, presented in this manuscript, resulted in an update of the Belgian recommendations for pneumococcal vaccination.
العلاقة: Vignette : https://kce.docressources.info/thumbnail.php?typeTest=1&id=1770; https://kce.docressources.info/index.php?lvl=notice_display&id=1770Test; 1770
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3دورية أكاديمية
المؤلفون: Brandes, J.
المساهمون: Visser, W.H., Farmer, M.V., Schuhl, A.L., Malbecq, W., Vrijens, France, Lines, C.R., Reines, S.A.
مصطلحات موضوعية: Acetates, Adult, Double-Blind Method, Female, Humans, Journal Article, Leukotriene Antagonists, Male, Migraine Disorders, Peer Review, prevention and control, R149, Treatment outcome, W 1 Serials. Periodicals
الوقت: 2008-52
الوصف: 581-6 ; OBJECTIVE: To evaluate the efficacy and tolerability of montelukast 20 mg in the prophylactic treatment of migraine. BACKGROUND: A previous small open-label study in migraine patients suggested prophylactic efficacy for montelukast, an antagonist of the cysteinyl leukotriene receptor that is used in the treatment of asthma. We sought to confirm these findings in a randomized controlled trial. METHODS: This multicenter, randomized, double-blind, placebo-controlled, parallel-groups study enrolled adult migraine outpatients who experienced > or =3 and < or =8 migraine attacks per month for the last 6 months. Patients were entered into a 2-month, single-blind, placebo run-in phase. Only patients who experienced > or =3 migraine attacks in the second month were eligible to enter the subsequent 3-month, double-blind treatment phase of the study. The primary efficacy endpoint was the percentage of patients reporting at least a 50% decrease in migraine attack frequency per month during the double-blind treatment period (months 3-5) compared to baseline (run-in month 2). RESULTS: A total of 93 patients were randomized to montelukast 20 mg and 84 patients to placebo at the end of the placebo run-in month 2; 76 patients on montelukast and 72 patients on placebo completed the double-blind treatment period. Over 3 months of treatment, there was no significant difference between the two groups in the percentage of patients who reported at least a 50% decrease in migraine attack frequency per month: 15.4% for montelukast versus 10.3% for placebo (P= .304). In addition, montelukast 20 mg was not significantly superior to placebo on any of the secondary endpoints. There were no differences between treatment groups for adverse events. CONCLUSION: Montelukast 20 mg was well tolerated in migraine patients but was not an effective prophylactic for prevention of migraine.
العلاقة: Vignette : https://kce.docressources.info/thumbnail.php?typeTest=1&id=2547; https://kce.docressources.info/index.php?lvl=notice_display&id=2547Test; 2547
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4دورية أكاديمية
المؤلفون: Van den Bruel, Ann
المساهمون: Aertgeerts, Bert, Buntinx, F., Hoppenbrouwers, K., Roelants, M.
مصطلحات موضوعية: W 1 Serials. Periodicals, Adult, Alcohols, Diagnosis, Epidemiology, Cross-Sectional Studies, Female, Humans, Mass Screening, Sensitivity and specificity, statistics and numerical data [Subheading], Students, Alcoholism, Journal Article, Peer Review, Great Britain
الوصف: 439-444 ; OBJECTIVES: The prevalence of alcohol abuse on college campuses ranges from 7 to 17%. Frequent heavy drinkers place themselves and others at risk for a variety of adverse consequences and frequently remain undetected. Brief individual interventions result in a significant reduction on the number of drinks. Therefore, detection of students at risk is useful and desirable. The CUGE has been elsewhere described as a promising screening device for problem drinking in students. In order to determine the diagnostic value of this new questionnaire, we set up a validation study in a new and independent population of freshmen. METHODS: A cross-sectional diagnostic study. Participants were college freshmen of the Katholieke Universiteit Leuven. All students received a questionnaire, containing the CUGE, being the test of interest, and the CIDI as the reference test. RESULTS: The CUGE combines a very high sensitivity of 91% with a reasonable specificity of 76.3% in this validation group. CONCLUSIONS: The CUGE is an excellent screening device in this population of students. In addition, it is a short questionnaire with only yes or no questions. This makes the CUGE easily applicable as a part of broad routine questionnaires.
العلاقة: Vignette : https://kce.docressources.info/thumbnail.php?typeTest=1&id=1789; https://kce.docressources.info/index.php?lvl=notice_display&id=1789Test; 1789
