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1دورية أكاديمية
المؤلفون: Thiry, Nancy
المساهمون: De Laet, Chris, Hulstaert, Frank, Neyt, Mattias, Huybrechts, Michel, Cleemput, Irina
مصطلحات موضوعية: W 1 Serials. Periodicals, Journal Article, Peer Review, Great Britain, Adolescent, Adult, Belgium, Child, Cohort Studies, Cost-Benefit Analysis, Female, Humans, Health Care Costs, Markov Chains, Mass Screening, Papillomavirus Vaccines, Quality-Adjusted Life Years
الوصف: 161-170 ; OBJECTIVES: The cost-effectiveness of adding a human papillomavirus (HPV) vaccination program in 12-year-old females to the recommended cervical cancer screening in Belgium is examined. Moreover, the health and economic consequences of a potential decline in screening uptake after initiation of a HPV vaccination program are investigated. METHODS: A static Markov model is developed to estimate the direct effect of vaccination on precancerous lesions and cervical cancers. RESULTS: Vaccination is estimated to avoid 20 percent of the cervical cancers occurring in a 12-year-old girls' cohort and to cost 32,665 euro per quality-adjusted life-year (QALY) gained (95 percent credibility interval [CrI]: 17,447 euro to 68,078 euro), assuming a booster injection after 10 years, a limited duration of protection and discounting costs and effects at 3 percent and 1.5 percent, respectively. Assuming lifelong protection, HPV vaccination is estimated to cost 14,382 euro (95 percent CrI: 9,238 euro to 25,644 euro) per QALY gained, while avoiding 50 percent of the cervical cancer cases. In the base-case, a 10 percent reduction in screening compliance after vaccination obliterates the effect of vaccination on cervical cancer cases avoided, whereas further declines in the level of screening compliance even turned out to be detrimental for the cohort's health, inducing a mean loss in QALYs and life-year gained compared with the situation prevaccination. CONCLUSIONS: An HPV vaccination program should only be considered if the level of screening after vaccination can be maintained.
العلاقة: Vignette : https://kce.docressources.info/thumbnail.php?typeTest=1&id=2200; https://kce.docressources.info/index.php?lvl=notice_display&id=2200Test; 2200
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2دورية أكاديمية
المؤلفون: Van den Bruel, Ann
المساهمون: Aertgeerts, Bert, Buntinx, F., Hoppenbrouwers, K., Roelants, M.
مصطلحات موضوعية: W 1 Serials. Periodicals, Adult, Alcohols, Diagnosis, Epidemiology, Cross-Sectional Studies, Female, Humans, Mass Screening, Sensitivity and specificity, statistics and numerical data [Subheading], Students, Alcoholism, Journal Article, Peer Review, Great Britain
الوصف: 439-444 ; OBJECTIVES: The prevalence of alcohol abuse on college campuses ranges from 7 to 17%. Frequent heavy drinkers place themselves and others at risk for a variety of adverse consequences and frequently remain undetected. Brief individual interventions result in a significant reduction on the number of drinks. Therefore, detection of students at risk is useful and desirable. The CUGE has been elsewhere described as a promising screening device for problem drinking in students. In order to determine the diagnostic value of this new questionnaire, we set up a validation study in a new and independent population of freshmen. METHODS: A cross-sectional diagnostic study. Participants were college freshmen of the Katholieke Universiteit Leuven. All students received a questionnaire, containing the CUGE, being the test of interest, and the CIDI as the reference test. RESULTS: The CUGE combines a very high sensitivity of 91% with a reasonable specificity of 76.3% in this validation group. CONCLUSIONS: The CUGE is an excellent screening device in this population of students. In addition, it is a short questionnaire with only yes or no questions. This makes the CUGE easily applicable as a part of broad routine questionnaires.
العلاقة: Vignette : https://kce.docressources.info/thumbnail.php?typeTest=1&id=1789; https://kce.docressources.info/index.php?lvl=notice_display&id=1789Test; 1789
