التفاصيل البيبلوغرافية
| العنوان: |
CYT387 restores Th17/Treg cell balance and inhibits mature osteoclast cell formation by regulating SOX-5 signaling in rheumatoid arthritis |
| المؤلفون: |
Srivastava, Susmita, Rasool, Mahaboobkhan |
| المصدر: |
Bangladesh Journal of Pharmacology; Vol. 18 No. 4 (2023); 138-151 ; 1991-0088 |
| بيانات النشر: |
Bangladesh Pharmacological Society |
| سنة النشر: |
2023 |
| المجموعة: |
Bangladesh Journals Online (BanglaJOL) |
| مصطلحات موضوعية: |
T helper 17 (Th17) cell, osteoclastogenesis, CYT387, IL-6 trans-signaling, janus kinases, rheumatoid arthritis |
| الوصف: |
The present study was conducted to investigate the therapeutic efficacy of CYT387 in rheumatoid arthritis pathogenesis concerning T helper 17 cell/regulatory T cell (Th17/Treg) imbalance and osteoclastogenesis. In this study, CYT 387 inhibited the proliferation of Th17 cells and collectively relocated FoxP3 + Treg cell differentiation in vitro. CYT387 mitigated the secretion of pathogenic IL-17 via reduced ROR-γt expression and restored the elevated expression of IL-10 by increasing FOXP3 activity. Alternatively, CYT387 abrogated RANKL expression and significantly increased osteoprotegerin levels by reducing SOX-5 activity. Furthermore, in a co-culture system of IL-6 and sIL-6R stimulated adjuvant-induced arthritic fibroblast-like synoviocytes and monocytes/macrophages collected from rat bone marrow, CYT387 reduced osteoclast formation and bone resorptive activity. In conclusion, CYT387 modulated IL-6/sIL-6R dependent JAK1/STAT3 activation and signaling mechanisms in CD4+T cells under Th17 differentiation conditions and osteoclast cells via dampened activation of SOX-5. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://www.banglajol.info/index.php/BJP/article/view/68901/47110Test; https://www.banglajol.info/index.php/BJP/article/view/68901Test |
| الإتاحة: |
https://www.banglajol.info/index.php/BJP/article/view/68901Test |
| حقوق: |
Copyright (c) 2023 Susmita Srivastava, Mahaboobkhan Rasool ; http://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.DD198960 |
| قاعدة البيانات: |
BASE |
