التفاصيل البيبلوغرافية
| العنوان: |
2,4,3',4'-tetramethoxy-biphenyl induces apoptosis in MGC-803 cells through a mitochondrial/caspase pathway |
| المؤلفون: |
Sui, Xin, Sun, Zhizhong, An, Weiwei, Cheng, Kai, Jiang, Shougang, Xianfeng, Gong |
| المصدر: |
Bangladesh Journal of Pharmacology; Vol. 9 No. 2 (2014); 235-243 ; 1991-0088 |
| بيانات النشر: |
Bangladesh Pharmacological Society |
| سنة النشر: |
2014 |
| المجموعة: |
Bangladesh Journals Online (BanglaJOL) |
| مصطلحات موضوعية: |
Apoptosis, Caspases, MGC-803 cells, Mitochondria, Tetramethoxybiphenyl |
| الوصف: |
Anti-proliferative and apoptosis-inducing effects of 2,4,3?,4?-tetramethoxy-biphenyl (TMBP) on human gastric cancer MGC-803 cells were investigated. The molecular mechanisms of TMBP-mediated tumor cell death were detected by clonogenic assay, staining with Hoechst 33258, DNA fragmentation assay, Western blot analysis and flow cytometry assay. Studies on MGC-803 cells treated with TMBP showed that TMBP inhibited the proliferation of MGC-803 cells in a time- and dose-dependent manner. The induction of apoptosis by TMBP was accompanied by the loss of mitochondrial membrane potential (ΔΨm), cytochrome C release and activation of caspase cascade, resulting in the cleavage of some specific substrates for caspase-3 such as poly (ADP-ribose) polymerase (PARP). In conclusion, these findings showed that TMBP may induce the apoptosis of MGC-803 through a mitochondrial/caspase pathway, suggesting its possible use for treating human cancers. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf; text/html; audio/mpeg; image/png |
| اللغة: |
English |
| العلاقة: |
https://www.banglajol.info/index.php/BJP/article/view/18430/13238Test; https://www.banglajol.info/index.php/BJP/article/view/18430/25668Test; https://www.banglajol.info/index.php/BJP/article/view/18430/29299Test; https://www.banglajol.info/index.php/BJP/article/view/18430/29300Test; https://www.banglajol.info/index.php/BJP/article/view/18430/29301Test; https://www.banglajol.info/index.php/BJP/article/view/18430/29302Test; https://www.banglajol.info/index.php/BJP/article/view/18430/29303Test; https://www.banglajol.info/index.php/BJP/article/view/18430/29304Test; https://www.banglajol.info/index.php/BJP/article/view/18430Test |
| الإتاحة: |
https://www.banglajol.info/index.php/BJP/article/view/18430Test |
| حقوق: |
Copyright (c) 2014 Xin Sui, Zhizhong Sun, Weiwei An, Kai Cheng, Shougang Jiang, Gong Xianfeng |
| رقم الانضمام: |
edsbas.3BCBA576 |
| قاعدة البيانات: |
BASE |
