دورية أكاديمية
Percutaneous mitral valve repair for mitral regurgitation in high-risk patients: results of the EVEREST II study
| العنوان: | Percutaneous mitral valve repair for mitral regurgitation in high-risk patients: results of the EVEREST II study |
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| المؤلفون: | Glower, Donald D, Kar, Saibal, Trento, Alfredo, Lim, D Scott, Bajwa, Tanvir, MD, Quesada, Ramon, Whitlow, Patrick L, Rinaldi, Michael J, Grayburn, Paul, Mack, Michael J, Mauri, Laura, McCarthy, Patrick M, Feldman, Ted |
| المصدر: | Cardiovascular Surgery |
| بيانات النشر: | Advocate Aurora Health Institutional Repository |
| سنة النشر: | 2014 |
| المجموعة: | Aurora Health Care Digital Repository |
| مصطلحات موضوعية: | high surgical risk, mitral valve insufficiency, Cardiology |
| الوصف: | BACKGROUND: The EVEREST II (Endovascular Valve Edge-to-Edge REpair STudy) High-Risk registry and REALISM Continued Access Study High-Risk Arm are prospective registries of patients who received the MitraClip device (Abbott Vascular, Santa Clara, California) for mitral regurgitation (MR) in the United States. OBJECTIVES: The purpose of this study was to report 12-month outcomes in high-risk patients treated with the percutaneous mitral valve edge-to-edge repair. METHODS: Patients with grades 3 to 4+ MR and a surgical mortality risk of ≥12%, based on the Society of Thoracic Surgeons risk calculator or the estimate of a surgeon coinvestigator following pre-specified protocol criteria, were enrolled. RESULTS: In the studies, 327 of 351 patients completed 12 months of follow-up. Patients were elderly (76 ± 11 years of age), with 70% having functional MR and 60% having prior cardiac surgery. The mitral valve device reduced MR to ≤2+ in 86% of patients at discharge (n = 325; p < 0.0001). Major adverse events at 30 days included death in 4.8%, myocardial infarction in 1.1%, and stroke in 2.6%. At 12 months, MR was ≤2+ in 84% of patients (n = 225; p < 0.0001). From baseline to 12 months, left ventricular (LV) end-diastolic volume improved from 161 ± 56 ml to 143 ± 53 ml (n = 203; p < 0.0001) and LV end-systolic volume improved from 87 ± 47 ml to 79 ± 44 ml (n = 202; p < 0.0001). New York Heart Association functional class improved from 82% in class III/IV at baseline to 83% in class I/II at 12 months (n = 234; p < 0.0001). The 36-item Short Form Health Survey physical and mental quality-of-life scores improved from baseline to 12 months (n = 191; p < 0.0001). Annual hospitalization rate for heart failure fell from 0.79% pre-procedure to 0.41% post-procedure (n = 338; p < 0.0001). Kaplan-Meier survival estimate at 12 months was 77.2%. CONCLUSIONS: The percutaneous mitral valve device significantly reduced MR, improved clinical symptoms, and decreased LV dimensions at 12 months in this ... |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://institutionalrepository.aah.org/cardiosurg/2Test |
| DOI: | 10.1016/j.jacc.2013.12.062 |
| الإتاحة: | https://doi.org/10.1016/j.jacc.2013.12.062Test https://institutionalrepository.aah.org/cardiosurg/2Test |
| رقم الانضمام: | edsbas.530559C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jacc.2013.12.062 |
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