دورية أكاديمية
Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development
| العنوان: | Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development |
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| المؤلفون: | Loponte S., Segre C. V., Senese S., Miccolo C., Santaguida S., Deflorian G., Citro S., Mattoscio D., Pisati F., Moser M. A., Visintin R., Seiser C., Chiocca S. |
| المساهمون: | Loponte, S., Segre, C. V., Senese, S., Miccolo, C., Santaguida, S., Deflorian, G., Citro, S., Mattoscio, D., Pisati, F., Moser, M. A., Visintin, R., Seiser, C., Chiocca, S. |
| سنة النشر: | 2016 |
| المجموعة: | ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| مصطلحات موضوعية: | Acetylation, Animal, Aurora Kinase, Genes, Regulator, Histone Deacetylase 1, Histone, Phosphorylation, Zebrafish, Embryonic Development, Mitosis |
| الوصف: | Histone deacetylases (HDACs) catalyze the removal of acetyl molecules from histone and non-histone substrates playing important roles in chromatin remodeling and control of gene expression. Class I HDAC1 is a critical regulator of cell cycle progression, cellular proliferation and differentiation during development; it is also regulated by many post-translational modifications (PTMs). Herein we characterize a new mitosis-specific phosphorylation of HDAC1 driven by Aurora kinases A and B. We show that this phosphorylation affects HDAC1 enzymatic activity and it is critical for the maintenance of a proper proliferative and developmental plan in a complex organism. Notably, we find that Aurora-dependent phosphorylation of HDAC1 regulates histone acetylation by modulating the expression of genes directly involved in the developing zebrafish central nervous system. Our data represent a step towards the comprehension of HDAC1 regulation by its PTM code, with important implications in unravelling its roles both in physiology and pathology. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27458029; info:eu-repo/semantics/altIdentifier/wos/WOS:000380200900001; volume:6; firstpage:30213; journal:SCIENTIFIC REPORTS; http://hdl.handle.net/11564/774519Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84979639495; https://www.nature.com/articles/srep30213Test |
| DOI: | 10.1038/srep30213 |
| الإتاحة: | https://doi.org/10.1038/srep30213Test http://hdl.handle.net/11564/774519Test https://www.nature.com/articles/srep30213Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1D0F54AE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/srep30213 |
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