دورية أكاديمية
Extended-amygdala intrinsic functional connectivity networks: A population study
| العنوان: | Extended-amygdala intrinsic functional connectivity networks: A population study |
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| المؤلفون: | Berry S. C., Wise R. G., Lawrence A. D., Lancaster T. M. |
| المساهمون: | Berry, S. C., Wise, R. G., Lawrence, A. D., Lancaster, T. M. |
| سنة النشر: | 2020 |
| المجموعة: | ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| مصطلحات موضوعية: | alcohol use, bed nucleus of the stria terminalis (BST/BNST), central nucleus of the amygdala (CeA), dispositional negativity, extended amygdala (ExtA), intrinsic functional connectivity (iFC), task-free functional magnetic resonance imaging (tf-fMRI) |
| الوصف: | Pre-clinical and human neuroimaging research implicates the extended-amygdala (ExtA) (including the bed nucleus of the stria terminalis [BST] and central nucleus of the amygdala [CeA]) in networks mediating negative emotional states associated with stress and substance-use behaviours. The extent to which individual ExtA structures form a functionally integrated unit is controversial. We utilised a large sample (n > 1,000 healthy young adult humans) to compare the intrinsic functional connectivity networks (ICNs) of the BST and CeA using task-free functional magnetic resonance imaging (fMRI) data from the Human Connectome Project. We assessed whether inter-individual differences within these ICNs were related to two principal components representing negative disposition and alcohol use. Building on recent primate evidence, we tested whether within BST-CeA intrinsic functional connectivity (iFC) was heritable and further examined co-heritability with our principal components. We demonstrate the BST and CeA to have discrete, but largely overlapping ICNs similar to previous findings. We found no evidence that within BST-CeA iFC was heritable; however, post hoc analyses found significant BST iFC heritability with the broader superficial and centromedial amygdala regions. There were no significant correlations or co-heritability associations with our principal components either across the ICNs or for specific BST-Amygdala iFC. Possible differences in phenotype associations across task-free, task-based, and clinical fMRI are discussed, along with suggestions for more causal investigative paradigms that make use of the now well-established ExtA ICNs. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33314443; info:eu-repo/semantics/altIdentifier/wos/WOS:000597729700001; firstpage:1; lastpage:23; numberofpages:23; journal:HUMAN BRAIN MAPPING; http://hdl.handle.net/11564/744426Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85097383169 |
| DOI: | 10.1002/hbm.25314 |
| الإتاحة: | https://doi.org/10.1002/hbm.25314Test http://hdl.handle.net/11564/744426Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E0FF0A1B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/hbm.25314 |
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