دورية أكاديمية
Impaired Functional Connectivity Unmasked by Simple Repetitive Motor Task in Early Relapsing-Remitting Multiple Sclerosis
| العنوان: | Impaired Functional Connectivity Unmasked by Simple Repetitive Motor Task in Early Relapsing-Remitting Multiple Sclerosis |
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| المؤلفون: | Petsas N., Tomassini V., Filippini N., Sbardella E., Tona F., Piattella M. C., Pozzilli C., Wise R. G., Pantano P. |
| المساهمون: | Petsas, N., Tomassini, V., Filippini, N., Sbardella, E., Tona, F., Piattella, M. C., Pozzilli, C., Wise, R. G., Pantano, P. |
| سنة النشر: | 2015 |
| المجموعة: | ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| مصطلحات موضوعية: | fMRI, functional connectivity, motor task, multiple sclerosi, resting state, Adult, Brain, Brain Mapping, Diffusion Tensor Imaging, Female, Gray Matter, Human, Magnetic Resonance Imaging, Male, Motor Activity, Multiple Sclerosis, Relapsing-Remitting, Neural Pathway, Regression Analysi, Rest |
| الوصف: | Background. Resting brain activity can be modulated by motor tasks to adapt to function. In multiple sclerosis (MS) patients, altered resting-state functional connectivity (RS-FC) has been reported and associated with impaired function and disability; little is known on how RS-FC is modulated by a simple repetitive motor task. Objective. To assess changes in RS-FC in early relapsing-remitting MS (RRMS) patients associated with repetitive thumb flexions (RTFs). Methods. A total of 20 right-handed patients with early RRMS and 14 healthy controls underwent a resting functional magnetic resonance imaging (fMRI) scan, before and after 25 minutes of alternate 30-s blocks of right RTF and rest. Dual-regression analysis of resting fMRI data followed the independent component analysis. Individual spatial maps of coherence between brain areas for 2 networks of interest, sensorimotor and cerebellar, were compared at the group level and correlated with measures of both clinical impairment and brain damage. Results. Significant RTF-induced differences in RS-FC were observed between groups in the cerebellar network because of increased RS-FC in patients but not in controls. In the sensorimotor network, the RS-FC after RTF increased in both groups, with no significant between-group differences. The sensorimotor and the cerebellar RS-FC were intercorrelated only in patients and only after the RTF. The sensorimotor RS-FC increase in patients correlated with structural MRI alterations. Conclusions. Our study unmasked RS-FC changes of motor-related networks occurring after a simple repetitive motor task in early RRMS patients only. Evaluation of altered RSN dynamics might prove useful for anticipating neuroplasticity and for MRI-informed neurorehabilitation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/25416740; info:eu-repo/semantics/altIdentifier/wos/WOS:000358313600007; volume:29; issue:6; firstpage:557; lastpage:565; numberofpages:9; journal:NEUROREHABILITATION AND NEURAL REPAIR; http://hdl.handle.net/11564/716891Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84936946705 |
| DOI: | 10.1177/1545968314558600 |
| الإتاحة: | https://doi.org/10.1177/1545968314558600Test http://hdl.handle.net/11564/716891Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F69CF8EC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1545968314558600 |
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