دورية أكاديمية
Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study
| العنوان: | Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study |
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| المؤلفون: | Gattermann, Norbert, Finelli, Carlo, Della Porta, Matteo, Fenaux, Pierre, Ganser, Arnold, Guerci Bresler, Agnes, Schmid, Mathias, Taylor, Kerry, Vassilieff, Dominique, Habr, Dany, Domokos, Gabor, Roubert, Bernard, Rose, Christian, Agaoglu, L., Alimena, G., Alonso, D., Ame, S., Angelucci, E., Arrizabalaga, B., Athanasiou Metaxa, M., Augustson, B., Aydinok, Y., Baba, A., Baccarani, M., Beck, J., Beris, P., Beyne Rauzy, O., Birgens, H., Bordessoule, D., Borgna Pignatti, C., Bosly, A., Bouabdallah, K., Bowden, D., Bowen, D., Bron, D., Cappellini, M. D., Capra, M., Cartron, G., Cazzola, M., Chalkias, C., Chan, L. L., Chancharunee, S., Chapman, C., Charoenkwan, P., Chasapopoulou, E., Cheze, S., Chuansumrit, A., Cianciulli, P., Dauriac, C., Delforge, M., Dölken, G., Dombret, H., Duyster, J., Economopoulos, T., Ehninger, G., Elalfy, M., El Beshlawy, A., Enggaard, L., Fillet, G., Filosa, A., Forni, G., Galanello, R., Gastl, G., Giraudier, S., Goldfarb, A., Grigg, A., Gumruk, F., Ha, S. Y., Haase, D., Heinrich, B., Hertzberg, M., Ho, J., Hsu, H. C., Huang, S., Hunault Berger, M., Inusa, B., Jaulmes, D., Jensen, J., Kattamis, A., Kilinc, Y., Kim, K. H., Kinsey, S., Kjeldsen, L., Koren, A., Lai, M. E., Lai, Y., Lee, J. W., Lee, K. H., Lee, S. H., Legros, L., Li, C., Li, C. K., Li, Q., Lin, K. H., Linkesch, W., Lübbert, M., Lutz, D., Mohamed Thalha, A. J., Mufti, G., Muus, P., Nobile, F., Papadopoulos, N., Perrotta, S., Pfeilstöcker, M., Piga, A., Poole, J., Porter, J. B., Pungolino, E., Quarta, G., Ravoet, C., Jolimont Lobbes, H. H., Remacha, A. F., Roy, L., Saglio, G., Sanz, G., Schmugge, M., Schots, H., Secchi, G., Seymour, J. F., Shah, F., Shah, H., Shen, Z., Slama, B., Sutcharitchan, P., Taher, A., Tamary, H., Tesch, H. J., Thein, S. L., Troncy, J., Villegas, A., Viprakasit, V., Wainwright, L., Wassmann, B., Wettervald, M., Will, A., Wörmann, B., Wright, J., Yeh, S. P., Yoon, S. S., Zoumbos, N. C., Zweegman, S., PETRINI, MARIO |
| المساهمون: | Gattermann, Norbert, Finelli, Carlo, Della Porta, Matteo, Fenaux, Pierre, Ganser, Arnold, Guerci Bresler, Agne, Schmid, Mathia, Taylor, Kerry, Vassilieff, Dominique, Habr, Dany, Domokos, Gabor, Roubert, Bernard, Rose, Christian, Agaoglu, L., Alimena, G., Alonso, D., Ame, S., Angelucci, E., Arrizabalaga, B., Athanasiou Metaxa, M., Augustson, B., Aydinok, Y., Baba, A., Baccarani, M., Beck, J., Beris, P., Beyne Rauzy, O., Birgens, H., Bordessoule, D., Borgna Pignatti, C., Bosly, A., Bouabdallah, K., Bowden, D., Bowen, D., Bron, D., Cappellini, M. D., Capra, M., Cartron, G., Cazzola, M., Chalkias, C., Chan, L. L., Chancharunee, S., Chapman, C., Charoenkwan, P., Chasapopoulou, E., Cheze, S., Chuansumrit, A., Cianciulli, P., Dauriac, C., Delforge, M., Dölken, G., Dombret, H., Duyster, J., Economopoulos, T., Ehninger, G., Elalfy, M., El Beshlawy, A., Enggaard, L., Fillet, G., Filosa, A., Forni, G., Galanello, R., Gastl, G., Giraudier, S., Goldfarb, A., Grigg, A., Gumruk, F., Ha, S. Y., Haase, D., Heinrich, B., Hertzberg, M., Ho, J., Hsu, H. C., Huang, S., Hunault Berger, M., Inusa, B., Jaulmes, D., Jensen, J., Kattamis, A., Kilinc, Y., Kim, K. H., Kinsey, S., Kjeldsen, L., Koren, A., Lai, M. E., Lai, Y., Lee, J. W., Lee, K. H., Lee, S. H., Legros, L., Li, C., Li, C. K., Li, Q., Lin, K. H., Linkesch, W., Lübbert, M., Lutz, D., Mohamed Thalha, A. J., Mufti, G., Muus, P. |
| سنة النشر: | 2010 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | Deferasirox, Iron chelation therapy, Labile plasma iron, Myelodysplastic syndrome, Serum ferritin, Adolescent, Adult, Aged, Alanine Transaminase, Benzoate, Child, Preschool, Female, Ferritin, Human, Iron Chelating Agent, Iron Overload, Male, Middle Aged, Triazole, Young Adult, Blood Transfusion, Cancer Research, Hematology, Oncology |
| الوصف: | The prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500. ng/mL, ∼50% were chelation-naïve. Overall median serum ferritin decreased significantly at 1 year (p=0.002). Decreases occurred irrespective of whether patients were chelation-naïve or previously chelated; changes were dependent on dose adjustments and ongoing iron intake. Sustained reductions in labile plasma iron were observed. Discontinuation rate (48.7%) and adverse event profile were consistent with previously reported deferasirox data in MDS. Alanine aminotransferase levels decreased significantly; change correlated significantly with reduction in serum ferritin (p<0.0001). This large dataset prospectively confirms the efficacy and well characterizes the safety profile of deferasirox in MDS. © 2010 Elsevier Ltd. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/20451251; info:eu-repo/semantics/altIdentifier/wos/WOS:000280576500009; volume:34; issue:9; firstpage:1143; lastpage:1150; numberofpages:8; journal:LEUKEMIA RESEARCH; http://hdl.handle.net/11568/803990Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-77955268192 |
| DOI: | 10.1016/j.leukres.2010.03.009 |
| الإتاحة: | https://doi.org/10.1016/j.leukres.2010.03.009Test http://hdl.handle.net/11568/803990Test |
| رقم الانضمام: | edsbas.7F35B50 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.leukres.2010.03.009 |
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