دورية أكاديمية
Reducing cholesterol and fat intake improves glucose tolerance by enhancing beta cell function in non-diabetic subjects
| العنوان: | Reducing cholesterol and fat intake improves glucose tolerance by enhancing beta cell function in non-diabetic subjects |
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| المؤلفون: | Tricò, Domenico, Trifirò, Silvia, MENGOZZI, ALESSANDRO, Morgantini, Cecilia, Baldi, Simona, Mari, Andrea, Natali, Andrea, TRICÒ, DOMENICO |
| المساهمون: | Tricò, Domenico, Trifirò, Silvia, Mengozzi, Alessandro, Morgantini, Cecilia, Baldi, Simona, Mari, Andrea, Natali, Andrea |
| سنة النشر: | 2018 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | TYPE-2 DIABETES-MELLITUS, INSULIN-SECRETION, HEALTHY-MEN, LDL-CHOLESTEROL, HDL-CHOLESTEROL, LIPID PRELOAD, IN-VIVO, SENSITIVITY, ACIDS, RISK |
| الوصف: | Context: A diet low in cholesterol and fat is commonly recommended to prevent metabolic and cardiovascular diseases; however, its effect on glucose tolerance is largely unknown. Objective: We examined whether and by which mechanisms a chronic reduction of cholesterol and fat intake affects glucose tolerance in nondiabetic individuals, independently of weight changes. Design and Participants: In this crossover, randomized clinical trial, 30 healthy subjects, including 15 with family history of type 2 diabetes (T2D) (T2D offspring), underwent a 75-g oral glucose tolerance test (OGTT) after two 14-day isocaloric high-cholesterol, high-fat (HChF) or low-cholesterol, and low-fat (LChF) diets. Main Outcome Measures: We evaluated changes in glucose tolerance, beta cell function, insulin clearance, and insulin sensitivity by modeling plasma glucose, insulin, and C-peptide levels during the OGTT. Results: The shift from the HChF to the LChF diet was neutral on body weight but increased glucose tolerance (mean glucose25%, P = 0.01) and three components of beta cell function: glucose sensitivity (+17%, P = 0.01), insulin secretion at fasting glucose (+20%, P = 0.02), and potentiation (+19%, P = 0.03). The LChF diet improved insulin sensitivity (+7%, P = 0.048) only in T2D offspring, who tended to be more susceptible to the positive effect of the diet on glucose tolerance. Conclusions: A chronic and isocaloric decrease in dietary cholesterol and fat intake improves glucose tolerance by diffusely ameliorating b cell function in nondiabetic subjects. Individuals genetically predisposed to develop T2D tend to be more susceptible to the positive effect of this dietary intervention on glucose tolerance and insulin sensitivity. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29095990; info:eu-repo/semantics/altIdentifier/wos/WOS:000424937300030; volume:103; issue:2; firstpage:622; lastpage:631; numberofpages:10; journal:THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM; http://hdl.handle.net/11568/885360Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85041928712 |
| DOI: | 10.1210/jc.2017-02089 |
| الإتاحة: | https://doi.org/10.1210/jc.2017-02089Test http://hdl.handle.net/11568/885360Test |
| رقم الانضمام: | edsbas.98E7D654 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/jc.2017-02089 |
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