المؤلفون: Savioli, Gabriele, Zanza, Christian, Longhitano, Yaroslava, Nardone, Alba, Varesi, Angelica, Ceresa, Iride Francesca, Manetti, Alice Chiara, Volonnino, Gianpietro, Maiese, Aniello, La Russa, Raffaele

المساهمون: Savioli, Gabriele, Zanza, Christian, Longhitano, Yaroslava, Nardone, Alba, Varesi, Angelica, Ceresa, Iride Francesca, Manetti, Alice Chiara, Volonnino, Gianpietro, Maiese, Aniello, La Russa, Raffaele

مصطلحات موضوعية: environmental heat emergency, heat emergency, heat stroke, hyperthermia

الوصف: Hyperthermia is an internal body temperature increase above 40.5 degrees C; normally internal body temperature is kept constant through natural homeostatic mechanisms. Heat-related illnesses occur due to exposure to high environmental temperatures in conditions in which an organism is unable to maintain adequate homeostasis. This can happen, for example, when the organism is unable to dissipate heat adequately. Heat dissipation occurs through evaporation, conduction, convection, and radiation. Heat disease exhibits a continuum of signs and symptoms ranging from minor to major clinical pictures. Minor clinical pictures include cramps, syncope, edema, tetany, and exhaustion. Major clinical pictures include heatstroke and life-threatening heat stroke and typically are expressed in the presence of an extremely high body temperature. There are also some categories of people at greater risk of developing these diseases, due to exposure in particular geographic areas (e.g., hot humid environments), to unchangeable predisposing conditions (e.g., advanced age, young age (i.e., children), diabetes, skin disease with reduced sweating), to modifiable risk factors (e.g., alcoholism, excessive exercise, infections), to partially modifiable risk factors (obesity), to certain types of professional activity (e.g., athletes, military personnel, and outdoor laborers) or to the effects of drug treatment (e.g., beta-blockers, anticholinergics, diuretics). Heat-related illness is largely preventable.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36289804; info:eu-repo/semantics/altIdentifier/wos/WOS:000872194500001; volume:10; issue:10; firstpage:2542; numberofpages:16; journal:BIOMEDICINES; https://hdl.handle.net/11568/1157467Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85140458712; https://www.mdpi.com/2227-9059/10/10/2542Test

الإتاحة: https://doi.org/10.3390/biomedicines10102542Test
https://hdl.handle.net/11568/1157467Test
https://www.mdpi.com/2227-9059/10/10/2542Test

المؤلفون: Nicolò Pietro Paolo Macciotta, Mariangela Caroprese, Roberta Ciampolini, Umberto Bernabucci, Alessandro Nardone

المساهمون: Pietro Paolo Macciotta, Nicolò, Caroprese, Mariangela, Ciampolini, Roberta, Bernabucci, Umberto, Nardone, Alessandro

مصطلحات موضوعية: Climate change (CC), livestock production, effects of Climate change on livestock production, selection for tolerance, adverse climatic conditions

الوصف: Climate change (CC) is one of the world’s major concerns. The rise of average temperatures, decrease of rainfalls, and increase of extreme weather events will affect agriculture, including livestock productions, in many areas of the world. Selection for tolerance to adverse weather conditions is one of the tools to mitigate the effects of CC on livestock production. An essential element is the choice of phenotypes. Physiological variables are difficult to measure on a large scale, but precision livestock farming can be of great help in this respect. The use of performance data combined with environmental variables is easier to apply, even if the results are strongly influenced by the mathematical-statistical models used. Given the complexity of the relationships with other phenotypes, resistance to adverse climatic conditions should be included in a selection index aggregated with other productive and functional traits. Genomics will provide a fundamental contribution to the understanding of the genetic determinism of the ability to adapt to climate change. In this context, local breeds are of great importance, as their genetic evolution has been largely driven by adaptation to environmental conditions. The use of genomic selection could speed up genetic progress in selection for tolerance to adverse climatic conditions.

وصف الملف: ELETTRONICO

العلاقة: volume:Supplemento agli Atti dei Georgofili 2021; issue:September 2021; firstpage:354; lastpage:365; numberofpages:12; journal:I GEORGOFILI; http://hdl.handle.net/11568/1112933Test; https://www.georgofili.net/articoli/i-georgofili-in-attesa-del-vertice-dei-ministri-dellagricoltura-del-g20/10942Test

الإتاحة: http://hdl.handle.net/11568/1112933Test
https://www.georgofili.net/articoli/i-georgofili-in-attesa-del-vertice-dei-ministri-dellagricoltura-del-g20/10942Test

المؤلفون: Reggidori N, Bucci L, Santi V, Stefanini B, Lani L, Rampoldi D, Ghittoni G, Farinati F, Masotto A, Mega A, Biasini E, Foschi FG, Svegliati- Baroni G, Sangiovanni A, Campani C, Raimondo G, Vidili G, Gasbarrini A, Celsa C, Di Marco M, Giannini EG, Sacco R, Brunetto MR, Azzaroli F, Magalotti D, Morisco F, Rapaccini GL, Nardone G, Vitale A, Trevisani F

المساهمون: Reggidori, N, Bucci, L, Santi, V, Stefanini, B, Lani, L, Rampoldi, D, Ghittoni, G, Farinati, F, Masotto, A, Mega, A, Biasini, E, Foschi, Fg, Svegliati- Baroni, G, Sangiovanni, A, Campani, C, Raimondo, G, Vidili, G, Gasbarrini, A, Celsa, C, Di Marco, M, Giannini, Eg, Sacco, R, Brunetto, Mr, Azzaroli, F, Magalotti, D, Morisco, F, Rapaccini, Gl, Nardone, G, Vitale, A, Trevisani, F

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37520672; info:eu-repo/semantics/altIdentifier/wos/WOS:001066142900001; volume:5; issue:8; firstpage:1; lastpage:14; numberofpages:14; journal:JHEP REPORTS; https://hdl.handle.net/11568/1216291Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85165586392; JHEP Rep. 2023 May 5;5(8):100784

الإتاحة: https://doi.org/10.1016/j.jhepr.2023.100784Test
https://hdl.handle.net/11568/1216291Test

المؤلفون: Pelizzaro F, Trevisani F, Simeon V, Vitale A, Cillo U, Piscaglia F, Missale G, Sangiovanni A, Foschi FG, Cabibbo G, Caturelli E, Di Marco M, Azzaroli F, Brunetto MR, Raimondo G, Vidili G, Guarino M, Gasbarrini A, Campani C, Svegliati-Baroni G, Giannini EG, Mega A, Masotto A, Rapaccini GL, Magalotti D, Sacco R, Nardone G, Farinati F

المساهمون: Pelizzaro, F, Trevisani, F, Simeon, V, Vitale, A, Cillo, U, Piscaglia, F, Missale, G, Sangiovanni, A, Foschi, Fg, Cabibbo, G, Caturelli, E, Di Marco, M, Azzaroli, F, Brunetto, Mr, Raimondo, G, Vidili, G, Guarino, M, Gasbarrini, A, Campani, C, Svegliati-Baroni, G, Giannini, Eg, Mega, A, Masotto, A, Rapaccini, Gl, Magalotti, D, Sacco, R, Nardone, G, Farinati, F

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37753540; info:eu-repo/semantics/altIdentifier/wos/WOS:001076719400001; volume:43; issue:12; firstpage:2762; lastpage:2775; numberofpages:14; journal:LIVER INTERNATIONAL; https://hdl.handle.net/11568/1216090Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85172136733

الإتاحة: https://doi.org/10.1111/liv.15719Test
https://hdl.handle.net/11568/1216090Test

المؤلفون: Gatta L., Nyssen O. P., Fiorini G., Saracino I. M., Pavoni M., Romano M., Gravina A. G., Granata L., Pellicano R., Gasbarrini A., Di Leo A., Losurdo G., Franceschi F., Nardone G., Rocco A., Dore M. P., Farinati F., Ghisa M., Bellini M., Holton J., Puig I., Vaira D., Borghi C., Megraud F., O'Morain C., Gisbert J. P.

المساهمون: Gatta, L., Nyssen, O. P., Fiorini, G., Saracino, I. M., Pavoni, M., Romano, M., Gravina, A. G., Granata, L., Pellicano, R., Gasbarrini, A., Di Leo, A., Losurdo, G., Franceschi, F., Nardone, G., Rocco, A., Dore, M. P., Farinati, F., Ghisa, M., Bellini, M., Holton, J., Puig, I., Vaira, D., Borghi, C., Megraud, F., O'Morain, C., Gisbert, J. P.

مصطلحات موضوعية: first-line treatment, H. pylori, Hp-EuReg, proton pump inhibitor, second-line treatment

الوصف: Background and Aims: The optimal management of naïve and not naïve Helicobacter pylori patients remains unclear. Therefore, it is essential to evaluate whether the actual clinical practice mirrors the indications suggested by the guidelines. This study aimed to assess the effectiveness and the safety of the empirical first- and second-line treatments prescribed to patients enroled at Italian centres participating in the European Registry on H. pylori Management (Hp-EuReg). Methods: The Hp-EuReg is an international multicentre prospective non-interventional registry starting in 2013 aiming to evaluate the management of H. pylori infection by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap. Variables assessed included demographics, previous eradication attempts, treatment regimen, effectiveness, and tolerance. Results: Overall, 3723 patients from 2013 to February 2021 were included: 2996 and 727 received an empirical first- and second-line treatment, respectively. According to the modified ITT analysis, among the first-line regimens, only the bismuth quadruple therapy with three-in-one-single capsule (BQT-TSC), the concomitant, and the sequential treatment - all lasting 10 days - achieved an eradication rate >90%. Among the second-line regimens, only the 10-day BQT-TSC reported an effectiveness >90%. High-dose PPI twice daily also significantly increased the effectiveness of some therapies. The BQT-TSC was the regimen with the highest incidence of adverse events. Conclusions: Only quadruple therapies lasting at least 10days achieved over 90% eradication rates among the empirical first- and second-line regimens. It remains unclear whether high-dose PPI twice daily can improve the efficacy of quadruple treatment.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36565017; info:eu-repo/semantics/altIdentifier/wos/WOS:000903677100001; volume:11; issue:1; firstpage:103; lastpage:113; numberofpages:11; journal:UNITED EUROPEAN GASTROENTEROLOGY JOURNAL; https://hdl.handle.net/11568/1168628Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85145076246

الإتاحة: https://doi.org/10.1002/ueg2.12348Test
https://hdl.handle.net/11568/1168628Test

المؤلفون: Di Iorio B. R., Bellasi A., Raphael K. L., Santoro D., Aucella F., Garofano L., Ceccarelli M., Di Lullo L., Capolongo G., Di Iorio M., Guastaferro P., Capasso G., Barbera V., Bruzzese A., Canale V., Conte G., Crozza V., Cupisti A., DeBlasio A., DeSimone E., DiMicco L., Fiorini F., Grifa R., Nardone R., Piemontese M., Sirico M. L., Vitale F.

المساهمون: Di Iorio, B. R., Bellasi, A., Raphael, K. L., Santoro, D., Aucella, F., Garofano, L., Ceccarelli, M., Di Lullo, L., Capolongo, G., Di Iorio, M., Guastaferro, P., Capasso, G., Barbera, V., Bruzzese, A., Canale, V., Conte, G., Crozza, V., Cupisti, A., Deblasio, A., Desimone, E., Dimicco, L., Fiorini, F., Grifa, R., Nardone, R., Piemontese, M., Sirico, M. L., Vitale, F.

مصطلحات موضوعية: Chronic kidney disease, Metabolic acidosi, Sodium bicarbonate

الوصف: Background: Metabolic acidosis is associated with accelerated progression of chronic kidney disease (CKD). Whether treatment of metabolic acidosis with sodium bicarbonate improves kidney and patient survival in CKD is unclear. Methods: We conducted a randomized (ratio 1:1). open-label, controlled trial (NCT number: NCT01640119. www.clinicaltrials.gov) to determine the effect in patients with CKD stage 3–5 of treatment of metabolic acidosis with sodium bicarbonate (SB) on creatinine doubling (primary endpoint), all-cause mortality and time to renal replacement therapy compared to standard care (SC) over 36-months. Parametric, non-parametric tests and survival analyses were used to assess the effect of SB on these outcomes. Results: A total of 376 and 364 individuals with mean (SD) age 67.8 (14.9) years, creatinine clearance 30 (12) ml/min, and serum bicarbonate 21.5 (2.4) mmol/l were enrolled in SB and SC, respectively. Mean (SD) follow-up was 29.6 (9.8) vs 30.3 (10.7) months in SC and SB. respectively. The mean (SD) daily doses of SB was 1.13 (0.10). 1.12 (0.11). and 1.09 (0.12) mmol/kg*bw/day in the first, second and third year of follow-up, respectively. A total of 87 participants reached the primary endpoint [62 (17.0%) in SC vs 25 (6.6%) in SB, p < 0.001). Similarly, 71 participants [45 (12.3%) in SC and 26 (6.9%) in SB, p = 0.016] started dialysis while 37 participants [25 (6.8%) in SC and 12 (3.1%) in SB, p = 0.004] died. There were no significant effect of SB on blood pressure, total body weight or hospitalizations. Conclusion: In persons with CKD 3–5 without advanced stages of chronic heart failure, treatment of metabolic acidosis with sodium bicarbonate is safe and improves kidney and patient survival.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31598912; info:eu-repo/semantics/altIdentifier/wos/WOS:000498618400014; volume:32; issue:6; firstpage:989; lastpage:1001; numberofpages:13; journal:JN. JOURNAL OF NEPHROLOGY; https://hdl.handle.net/11568/1018664Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85074011152; http://www.springer.com/medicine/nephrology/journal/40620Test

الإتاحة: https://doi.org/10.1007/s40620-019-00656-5Test
https://hdl.handle.net/11568/1018664Test
http://www.springer.com/medicine/nephrology/journal/40620Test

المؤلفون: Bernardeschi, Cinzia, Mercaldo, Francesco, Nardone, Vittoria, Santone, Antonella

المساهمون: Bernardeschi, Cinzia, Mercaldo, Francesco, Nardone, Vittoria, Santone, Antonella

مصطلحات موضوعية: malware, botnet, Android, model checking, formal methods, temporal logic, security

الوصف: Android malware is increasing from the point of view of the complexity and the harmful actions. As a matter fact, malware writers are developing sophisticated techniques to infect mobile devices very closed to their counterpart for personal computers. One of these threats is represented by the possibility to control the infected devices from the attacker i.e., the so-called botnet. In this paper a method able to identify botnet in Android environment through model checking is proposed. Starting from the malicious payload definition, the proposed method is able to detect and to localize the code related to the malicious botnet. We experiment real-world botnet based Android malware, obtaining encouraging results.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000571151500099; volume:159; firstpage:963; lastpage:972; numberofpages:10; journal:PROCEDIA COMPUTER SCIENCE; http://hdl.handle.net/11568/1016574Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85076259247; https://www.sciencedirect.com/science/article/pii/S1877050919314590Test

الإتاحة: https://doi.org/10.1016/j.procs.2019.09.263Test
http://hdl.handle.net/11568/1016574Test
https://www.sciencedirect.com/science/article/pii/S1877050919314590Test

المؤلفون: Chappell, Elizabeth, Riordan, Andrew, Jourdain, Gonzague, Soriano-Arandes, Antoni, Ene, Luminita, Scherpbier, Henriette J, Warszawski, Josiane, Collins, Intira J, Smit, Colette, Marques, Laura, Klein, Nigel, Guillén, Sara, Judd, Ali, Thorne, Claire, Goodall, Ruth, Königs, Christoph, Spoulou, Vana, Prata, Filipa, Goetghebuer, Tessa, Chiappini, Elena, Galli, Luisa, Naver, Lars, Giaquinto, Carlo, Gibb, Diana M, Marczynska, Magdalena, Okhonskaia, Liubov, Klimkait, Thomas, Lallemant, Marc, Ngo-Giang-Huong, Nicole, Kiseleva, Galyna, Malyuta, Ruslan, Volokha, Alla, Hainaut, Marc, Delforge, Marc, Le Chenadec, Jerome, Ramos, Elisa, Dialla, Olivia, Wack, Thierry, Laurent, Corine, Ait si Selmi, Lamya, Leymarie, Isabelle, Ait Benali, Fazia, Brossard, Maud, Boufassa, Leila, Floch-Tudal, Corinne, Firtion, Ghislaine, Hau, Isabelle, Chace, Anne, Bolot, Pascal, Blanche, Stéphane, Levine, Martine, Bicëtre, Le Kremlin, Fourcade, Corinne, Heller-Roussin, Brigitte, Runel-Belliard, Camille, Tricoire, Joëlle, Chirouze, Catherine, Reliquet, Véronique, Brouard, Jacques, Kebaili, Kamila, Fialaire, Pascale, Lalande, Muriel, Schultze-Strasser, Stephan, Baumann, U, Niehues, T, Neubert, J, Kobbe, R, Berlin, Charite, Feiterna-Sperling, C, Königs, C, Buchholz, B, Notheis, G, de Martino, Maurizio, Angelo Tovo, Pier, Patrizia, Osimani, Larovere, Domenico, Ruggeri, Maurizio, Faldella, Giacomo, Baldi, Francesco, Badolato, Raffaele, Montagnani, Carlotta, Venturini, Elisabetta, Lisi, Catiuscia, Di Biagio, Antonio, Taramasso, Lucia, Giacomet, Vania, Erba, Paola, Esposito, Susanna, Lipreri, Rita, Salvini, Filippo, Tagliabue, Claudia, Cellini, Monica, Bruzzese, Eugenia, Lo Vecchio, Andrea, Rampon, Osvalda, Donà, Daniele, Romano, Amelia, Dodi, Icilio, Maccabruni, Anna, Consolini, Rita, Bernardi, Stefania, Tchidjou Kuekou, Hyppolite, Genovese, Orazio, Olmeo, Paolina, Cristiano, Letizia, Mazza, Antonio, Gabiano, Clara, Garazzino, Silvia, Pellegatta, Antonio, Pajkrt, D, Scherpbier, H J, Weijsenfeld, A M, de Boer, C G, Jurriaans, S, Back, N K T, Zaaijer, H L, Berkhout, B, Cornelissen, M T E, Schinkel, C J, Wolthers, K C, Fraaij, P L A, van Rossum, A M C, van der Knaap, L C, Visser, E G, Koopmans, M P G, van Kampen, J J A, Pas, S D, Henriet, S S V, van de Flier, M, van Aerde, K, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, F F, Schölvinck, E H, de Groot-de Jonge, H, Niesters, H G M, van Leer-Buter, C C, Knoester, M, Bont, L J, Geelen, S P M, Wolfs, T F W, Nauta, N, Ang, C W, van Houdt, R, Pettersson, A M, Vandenbroucke-Grauls, C M J E, Reiss, P, Bezemer, D O, van Sighem, A I, Smit, C, Wit, F W M N, Boender, T S, Zaheri, S, Hillebregt, M, de Jong, A, Bergsma, D, Grivell, S, Jansen, A, Raethke, M, Meijering, R, de Groot, L, van den Akker, M, Bakker, Y, Claessen, E, El Berkaoui, A, Koops, J, Kruijne, E, Lodewijk, C, Munjishvili, L, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Rutkens, T, Schoorl, M, Timmerman, A, Tuijn, E, Veenenberg, L, van der Vliet, S, Wisse, A, Woudstra, T, Tuk, B, Popielska, Jolanta, Pokorska-Śpiewak, Maria, Ołdakowska, Agnieszka, Zawadka, Konrad, Coupland, Urszula, DorobaLaura Marques, Małgorzata, Teixeira, Carla, Fernandes, Alexandre, Voronin, Evgeny, Miloenko, Milana, Labutina, Svetlana, Tomás Ramos, José, Prieto, Luis, Luisa Navarro, María, Saavedra, Jesús, Santos, Mar, Angeles Muñoz, Ma, Ruiz, Beatriz, Mc Phee, Carolina Fernandez, de Ory, Santiago Jimenez, Alvarez, Susana, Ángel Roa, Miguel, Beceiro, José, Martínez, Jorge, Badillo, Katie, Apilanez, Miren, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Gómez Sirvent, Jorge, Garzón, Mónica, Román, Vicente, Montesdeoca, Abián, Mateo, Mercedes, José Muñoz, María, Angulo, Raquel, Neth, Olaf, Falcón, Lola, Terol, Pedro, Luis Santos, Juan, Moreno, David, Lendínez, Francisco, Grande, Ana, José Romero, Francisco, Lillo, Miguel, Losada, Begoña, Herranz, Mercedes, Bustillo, Matilde, Guerrero, Carmelo, Collado, Pilar, Antonio Couceiro, José, Pérez, Amparo, Isabel Piqueras, Ana, Bretón, Rafael, Segarra, Inmaculada, Gavilán, César, Jareño, Enrique, Montesinos, Elena, Dapena, Marta, Álvarez, Cristina, Gloria Andrés, Ana, Marugán, Víctor, Ochoa, Carlos, Alfayate, Santiago, Isabel Menasalvas, Ana, de Miguel, Elisa, Aebi-Popp, K, Asner, S, Aubert, V, Battegay, M, Baumann, M, Bernasconi, E, Böni, J, Brazzola, P, Bucher, H C, Calmy, A, Cavassini, M, Ciuffi, A, Duppenthaler, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Francini, K, Furrer, H, Fux, C A, Grawe, C, Günthard, H F, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kovari, H, Kouyos, R D, Ledergerber, B, Martinetti, G, de Tejada, B Martinez, Metzner, K J, Müller, N, Nicca, D, Paioni, P, Pantaleo, G, Polli, Ch, Posfay-Barbe, K, Rauch, A, Rudin, C, Schmid, P, Scherrer, A U, Speck, R, Tarr, P, Thanh Lecompte, M, Trkola, A, Vernazza, P, Wagner, N, Wandeler, G, Weber, R, Wyler, C A, Yerly, S, Techakunakorn, Pornchai, Hansudewechakul, Rawiwan, Kham, Chiang, Wanchaitanawong, Vanichaya, Theansavettrakul, Sookchai, Sai, Mae, Nanta, Sirisak, Ngampiyaskul, Chaiwat, Phanomcheong, Siriluk, Hongsiriwon, Suchat, Karnchanamayul, Warit, Kwanchaipanich, Ratchanee, Kanjanavanit, Suparat, Kamonpakorn, Nareerat, Nantarukchaikul, Maneeratn, Layangool, Prapaisri, Mekmullica, Jutarat, Lucksanapisitkul, Paiboon, Watanayothin, Sudarat, Lertpienthum, Narong, Warachit, Boonyarat, Hanpinitsak, Sansanee, Potchalongsin, Sathit, Thanasiri, Pimpraphai, Krikajornkitti, Sawitree, Attavinijtrakarn, Pornsawan, Srirojana, Sakulrat, Bunjongpak, Suthunya, Puangsombat, Achara, Na-Rajsima, Sathaporn, Ananpatharachai, Pornchai, Akarathum, Noppadon, Phuket, Vachira, Lawtongkum, Weerasak, Kheunjan, Prapawan, Suriyaboon, Thitiporn, Saipanya, Airada, Than-in-at, Kanchana, Jaisieng, Nirattiya, Suaysod, Rapeepan, Chailoet, Sanuphong, Naratee, Naritsara, Kawilapat, Suttipong, Kaleeva, T, Baryshnikova, Y, Soloha, S, Bashkatova, N, Raus, I, Glutshenko, O, Ruban, Z, Prymak, N, Kiseleva, G, Bailey, H, Bamford, Alasdair, Butler, Karina, Doerholt, Katja, Doherty, Conor, Foster, Caroline, Francis, Kate, Harrison, Ian, Kenny, Julia, Letting, Gillian, McMaster, Paddy, Murau, Fungai, Nsangi, Edith, Peters, Helen, Prime, Katia, Shackley, Fiona, Shingadia, Delane, Storey, Sharon, Tudor-Williams, Gareth, Turkova, Anna, Welch, Steve, Jeannie Collins, Intira, Cook, Claire, Crichton, Siobhan, Dobson, Donna, Fairbrother, Keith, M Gibb, Diana, Harper, Lynda, Le Prevost, Marthe, Van Looy, Nadine, Butler, K, Walsh, A, Thrasyvoulou, L, Welch, S, Bernatoniene, J, Manyika, F, Sharpe, G, Subramaniam, B, Sloper, K, Fidler, K, Hague, R, Price, V, Clapson, M, Flynn, J, Cardoso, A, Abou-Rayyah, M, Klein, N, Shingadia, D, Gurtin, D, Yeadon, S, SegalC Ball, S, Hawkins, S, Dowie, M, Bandi, S, Percival, E, Eisenhut, M, Duncan, K, Clough, S, Anguvaa, L, Conway, S, Flood, T, Pickering, A, McMaster, P, Murphy, C, Daniels, J, Lees, Y, Thompson, F, Williams, B, Pope, S, Cliffe, L, Smyth, A, Southall, S, Freeman, A, Freeman, H, Christie, S, Gordon, A, Rogahn, D, Clarke, L, Jones, L, Offerman, B, Greenberg, M, Benson, C, Riordan, A, Ibberson, L, Shackley, F, Faust, S N, Hancock, J, Doerholt, K, Prime, K, Sharland, M, Storey, S, Lyall, H, Monrose, C, Seery, P, Tudor-Williams, G, Menson, E, Callaghan, A, Bridgwood, A, Evans, J, Blake, E, Yannoulias, A, Critchton, Siobhan, Duff, Charlotte, Gomezpena, Daniel, Lundin, Rebecca, Mangiarini, Laura, Nardone, Alessandra

المساهمون: Chappell, Elizabeth, Riordan, Andrew, Jourdain, Gonzague, Soriano-Arandes, Antoni, Ene, Luminita, Scherpbier, Henriette J, Warszawski, Josiane, Collins, Intira J, Smit, Colette, Marques, Laura, Klein, Nigel, Guillén, Sara, Judd, Ali, Thorne, Claire, Goodall, Ruth, Königs, Christoph, Spoulou, Vana, Prata, Filipa, Goetghebuer, Tessa, Chiappini, Elena, Galli, Luisa, Naver, Lar, Giaquinto, Carlo, Gibb, Diana M, Marczynska, Magdalena, Okhonskaia, Liubov, Klimkait, Thoma, Lallemant, Marc, Ngo-Giang-Huong, Nicole, Kiseleva, Galyna, Malyuta, Ruslan, Volokha, Alla, Hainaut, Marc, Delforge, Marc, Le Chenadec, Jerome, Ramos, Elisa, Dialla, Olivia, Wack, Thierry, Laurent, Corine, Ait si Selmi, Lamya, Leymarie, Isabelle, Ait Benali, Fazia, Brossard, Maud, Boufassa, Leila, Floch-Tudal, Corinne, Firtion, Ghislaine, Hau, Isabelle, Chace, Anne, Bolot, Pascal, Blanche, Stéphane, Levine, Martine, Bicëtre, Le Kremlin, Fourcade, Corinne, Heller-Roussin, Brigitte, Runel-Belliard, Camille, Tricoire, Joëlle, Chirouze, Catherine, Reliquet, Véronique, Brouard, Jacque, Kebaili, Kamila, Fialaire, Pascale, Lalande, Muriel, Schultze-Strasser, Stephan, Baumann, U, Niehues, T, Neubert, J, Kobbe, R, Berlin, Charite, Feiterna-Sperling, C, Königs, C, Buchholz, B, Notheis, G, de Martino, Maurizio, Angelo Tovo, Pier, Patrizia, Osimani, Larovere, Domenico, Ruggeri, Maurizio, Faldella, Giacomo, Baldi, Francesco, Badolato, Raffaele, Montagnani, Carlotta, Venturini, Elisabetta, Lisi, Catiuscia, Di Biagio, Antonio, Taramasso, Lucia, Giacomet, Vania, Erba, Paola, Esposito, Susanna, Lipreri, Rita, Salvini, Filippo, Tagliabue, Claudia, Cellini, Monica, Bruzzese, Eugenia, Lo Vecchio, Andrea, Rampon, Osvalda, Donà, Daniele

مصطلحات موضوعية: antiretroviral therapy, children, HIV, poor immune response, viral suppression

الوصف: BACKGROUND: In human immunodeficiency virus (HIV)-positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART. METHODS: Sixteen cohorts from the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) contributed data. Children <18 years at ART initiation, with sustained viral suppression (VS) (≤400 copies/mL) for ≥1 year were included. The prevalence of PIR (defined as World Health Organization advanced/severe immunosuppression for age) at 1 year of VS was described. Factors associated with PIR were assessed using logistic regression. Rates of acquired immunodeficiency syndrome (AIDS) or death on suppressive ART were calculated by PIR status. RESULTS: Of 2318 children included, median age was 6.4 years and 68% had advanced/severe immunosuppression at ART initiation. At 1 year of VS, 12% had PIR. In multivariable analysis, PIR was associated with older age and worse immunological stage at ART start, hepatitis B coinfection, and residing in Thailand (all P ≤ .03). Rates of AIDS/death (95% confidence interval) per 100 000 person-years were 1052 (547, 2022) among PIR versus 261 (166, 409) among immune responders; rate ratio of 4.04 (1.83, 8.92; P < .001). CONCLUSIONS: One in eight children in our cohort experienced PIR despite sustained VS. While the overall rate of AIDS/death was low, children with PIR had a 4-fold increase in risk of event as compared with immune responders.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30919882; info:eu-repo/semantics/altIdentifier/wos/WOS:000520513200018; volume:70; issue:3; firstpage:404; lastpage:415; numberofpages:12; journal:CLINICAL INFECTIOUS DISEASES; https://hdl.handle.net/11568/1030628Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85077947611; https://academic.oup.com/cid/article/70/3/404/5421269Test

الإتاحة: https://doi.org/10.1093/cid/ciz253Test
https://hdl.handle.net/11568/1030628Test
https://academic.oup.com/cid/article/70/3/404/5421269Test

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المساهمون: Mishra, Anu, Zhou, Bin, Rodriguez-Martinez, Andrea, Bixby, Honor, Singleton, Rosie K., Carrillo-Larco, Rodrigo M., Sheffer, Kate E., Paciorek, Christopher J., Bennett, James E., Lhoste, Victor, Iurilli, Maria L. C., Di Cesare, Mariachiara, Bentham, Jame, Phelps, Nowell H., Sophiea, Marisa K., Stevens, Gretchen A., Danaei, Goodarz, Cowan, Melanie J., Savin, Stefan, Riley, Leanne M., Gregg, Edward W., Aekplakorn, Wichai, Ahmad, Noor Ani, Baker, Jennifer L., Chirita-Emandi, Adela, Farzadfar, Farshad, Fink, Günther, Heinen, Mirjam, Ikeda, Nayu, Kengne, Andre P., Khang, Young-Ho, Laatikainen, Tiina, Laxmaiah, Avula, Ma, Jun, Monroy-Valle, Michele, Mridha, Malay K., Padez, Cristina P., Reynolds, Andrew, Sorić, Maroje, Starc, Gregor, Wirth, James P., Abarca-Gómez, Leandra, Abdeen, Ziad A., Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Abdul Rahim, Hanan F., Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M., Garba, Jamila Abubakar, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Adams, Robert J., Adu-Afarwuah, Seth, Afsana, Kaosar, Afzal, Shoaib, Agbor, Valirie N., Agdeppa, Imelda A., Aghazadeh-Attari, Javad, Aguenaou, Hassan, Aguilar-Salinas, Carlos A., Agyemang, Charle, Ahmad, Mohamad Hasnan, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Imran, Ahmed, Soheir H., Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M., Al-Lahou, Badreya, Al-Raddadi, Rajaa, Al Hourani, Huda M., Al Qaoud, Nawal M., Alarouj, Monira, Albuhairan, Fadia, Aldhukair, Shahla, Aldwairji, Maryam A., Alexius, Sylvia, Ali, Mohamed M., Alkandari, Abdullah, Alkerwi, Ala’A, Alkhatib, Buthaina M., Allin, Kristine, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N., Etxezarreta, Pilar Amiano, Amoah, John, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A., Androutsos, Odyssea, Ängquist, Lar, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena

الوصف: Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1-6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5-19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-incomecountries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m-2 in the vast majority ofcountries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36991188; volume:615; issue:7954; firstpage:874; lastpage:883; numberofpages:10; journal:NATURE; https://hdl.handle.net/11568/1172305Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85151221457

الإتاحة: https://doi.org/10.1038/s41586-023-05772-8Test
https://hdl.handle.net/11568/1172305Test

المؤلفون: Martinelli F., Mercaldo F., Nardone V., Santone A., Vaglini G.

المساهمون: Martinelli, F., Mercaldo, F., Nardone, V., Santone, A., Vaglini, G.

مصطلحات موضوعية: Android, Formal method, Malware, Model checking, Security

الوصف: Typically, when a platform is widely disseminated, malicious writers focus their attention in order to perpetrate attacks on the widespread environment. This is the reason why nowadays there exists a series of attacks targeting the Android operating system, the most common platform available for mobile devices. In this paper we present a tool implementing a model checking-based approach to identify Android malware. Furthermore, the tool is also useful to localize the malicious behaviour of the application under analysis code. We evaluate the effectiveness of the tool on real-world samples belonging to the HummingBad malware family, one of the most recent and aggressive Android threats.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-3-030-32257-1; info:eu-repo/semantics/altIdentifier/isbn/978-3-030-32258-8; info:eu-repo/semantics/altIdentifier/wos/WOS:000570007800057; ispartofbook:Studies in Computational Intelligence; 13th International Symposium on Intelligent Distributed Computing, IDC 2019; volume:868; firstpage:485; lastpage:494; numberofpages:10; serie:STUDIES IN COMPUTATIONAL INTELLIGENCE; http://hdl.handle.net/11568/1047733Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85075566299

الإتاحة: https://doi.org/10.1007/978-3-030-32258-8_57Test
http://hdl.handle.net/11568/1047733Test