دورية أكاديمية
Sudden Death Associated with Complex Treatment of Acute Mania: Case Report and Toxicological Findings
| العنوان: | Sudden Death Associated with Complex Treatment of Acute Mania: Case Report and Toxicological Findings |
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| المؤلفون: | Curto, Martina, Lionetto, Luana, David, Maria Chiara, Maiese, Aniello, Ferracuti, Stefano, Simmaco, Maurizio, Baldessarini, Ross J. |
| المساهمون: | Curto, Martina, Lionetto, Luana, David, Maria Chiara, Maiese, Aniello, Ferracuti, Stefano, Simmaco, Maurizio, Baldessarini, Ross J. |
| سنة النشر: | 2019 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | Antipsychotic, arrhythmia, drug-drug interaction, sudden death, valproate, psychotropic drugs |
| الوصف: | Background: Antipsychotic drugs, mood-stabilizers, and sedatives are used rou- tinely to treat acute mania, sometimes in combinations, most of which are poorly evaluated for efficacy and safety. Objective: We report a case of sudden death in a 40-year-old man with acute mania treated aggressively with combinations of drugs that resulted in in potentially toxic, high serum drug concentrations. Methods: After the autopsy, analysis were conducted to determine levels of the adminis- tered medications using GC-MS and LC-MS/MS. Results: Although dosed within recommended ranges, circulating concentrations of some antipsychotic drugs given were excessive, suggesting possible pharmacokinetic interactions. In particular, valproate may have increased serum levels of haloperidol, clozapine, and promazine. The proposed cause of death was cardiac arrest, to which the high concentrations of antipsychotics may have contributed. Conclusion: This case suggests caution in the aggressive treatment of mania with combinations of psychotropic drugs and highlights the need of further clinical studies to identify consequences of drug-drug interactions of antimanic drugs, even when given at recommended doses. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | volume:8; issue:3; firstpage:238; lastpage:243; numberofpages:6; journal:CURRENT PSYCHOPHARMACOLOGY; http://hdl.handle.net/11568/1062179Test |
| DOI: | 10.2174/2211556008666190916093915 |
| الإتاحة: | https://doi.org/10.2174/2211556008666190916093915Test http://hdl.handle.net/11568/1062179Test |
| رقم الانضمام: | edsbas.2D404FF7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/2211556008666190916093915 |
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