دورية أكاديمية
A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth
| العنوان: | A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth |
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| المؤلفون: | Galderisi, Alfonso, Tricò, Domenico, Pierpont, Bridget, Shabanova, Veronika, Samuels, Stephanie, Dalla Man, Chiara, Galuppo, Brittany, Santoro, Nicola, Caprio, Sonia |
| المساهمون: | Galderisi, Alfonso, Tricò, Domenico, Pierpont, Bridget, Shabanova, Veronika, Samuels, Stephanie, Dalla Man, Chiara, Galuppo, Brittany, Santoro, Nicola, Caprio, Sonia |
| سنة النشر: | 2020 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| الوصف: | The risk genotype for the common variant rs7903146 of the transcription factor 7-like-2 (TCF7L2) gene has been found to affect the incretin response in healthy and obese adults; however, whether a similar functional defect is also present in obese adolescents remains unexplored. Herein, we examined the functional effect of the rs7903146 variant in the TCF7L2 gene on the incretin effect and determined its translational metabolic manifestation by performing deep phenotyping of the incretin system, β-cell function relative to insulin sensitivity, the gastrointestinal-induced glucose disposal (GIGD) in obese youth with normal and impaired glucose tolerance. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32788279; info:eu-repo/semantics/altIdentifier/wos/WOS:000571872200056; firstpage:dc200445; journal:DIABETES CARE; http://hdl.handle.net/11568/1051036Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85091470245 |
| DOI: | 10.2337/dc20-0445 |
| الإتاحة: | https://doi.org/10.2337/dc20-0445Test http://hdl.handle.net/11568/1051036Test |
| رقم الانضمام: | edsbas.8D44286B |
| قاعدة البيانات: | BASE |
| DOI: | 10.2337/dc20-0445 |
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