دورية أكاديمية
Beta-catenin activation is not involved in sporadic parathyroid carcinomas and adenomas
| العنوان: | Beta-catenin activation is not involved in sporadic parathyroid carcinomas and adenomas |
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| المؤلفون: | CETANI F, PARDI E, BANTI C, COLLECCHI P, VIACAVA P, BORSARI S, FANELLI G, NACCARATO AG, SAPONARO F, BERTI P, MICCOLI P, PINCHERA A, MARCOCCI C |
| المساهمون: | Cetani, F, Pardi, E, Banti, C, Collecchi, P, Viacava, P, Borsari, S, Fanelli, G, Naccarato, Ag, Saponaro, F, Berti, P, Miccoli, P, Pinchera, A, Marcocci, C |
| سنة النشر: | 2010 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | Adenoma, Carcinoma, Cell Transformation, Neoplastic, Cytoplasm, DNA Mutational Analysis, Exons, Humans, Membrane Proteins, Neoplasm Proteins Parathyroid Neoplasms, Signal Transduction, Wnt Proteins, beta Catenin, Endocrinology, Oncology, Cancer Research, Diabetes and Metabolism |
| الوصف: | Aberrant accumulation of beta-catenin has been found in various types of human tumors. The aim of this study was to evaluate whether Wnt/beta-catenin signaling is activated in parathyroid carcinomas and adenomas. We studied 154 parathyroid tumors (18 carcinomas (13 with distant metastases), six atypical adenomas, and 130 adenomas). Three normal parathyroid tissues were used as control. Direct sequencing of exon 3 of the CTNNB1 gene showed absence of stabilizing mutations in all the tumors. Immunostaining of beta-catenin was performed in all carcinomas and in 66 adenomas (including three atypical). Normal parathyroid showed a homogeneous distinct outer cell membrane staining in the majority of cells and no nuclear staining. A weak cytoplasmic staining was observed in one case. All tumors showed negative nuclear staining. With the exception of one carcinoma, which had a negative membrane staining, all other samples showed a membrane staining which was similar to that of the normal parathyroid. beta-Catenin expression was heterogeneous with a range of positive cells between 5 and 80%, independently of tumor type. Our results suggest that the Wnt/beta-catenin signaling pathway is not involved in the development of parathyroid carcinomas and adenomas. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/19755524; info:eu-repo/semantics/altIdentifier/wos/WOS:000275663100001; volume:17; firstpage:1; lastpage:6; numberofpages:6; journal:ENDOCRINE-RELATED CANCER; http://hdl.handle.net/11568/200184Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-77449145777 |
| DOI: | 10.1677/ERC-09-0147 |
| الإتاحة: | https://doi.org/10.1677/ERC-09-0147Test http://hdl.handle.net/11568/200184Test |
| رقم الانضمام: | edsbas.A4B87338 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1677/ERC-09-0147 |
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