المؤلفون: Stratta, Robert J, Lo, Agnes, Shokouh Amiri, M. Hosein, Gaber, Lillian W, Gaber, A. Osama, EGIDI, MARIA FRANCESCA

المساهمون: Stratta, Robert J, Lo, Agne, Shokouh Amiri, M. Hosein, Egidi, MARIA FRANCESCA, Gaber, Lillian W, Gaber, A. Osama

مصطلحات موضوعية: Adult, Animal, Antilymphocyte Serum, Diabetes Mellitus, Type 1, Drainage, Drug Therapy, Combination, Female, Graft Survival, Human, Immunosuppression, Male, Middle Aged, Mycophenolic Acid, Pancreas Transplantation, Portal System, Rabbit, Reoperation, Retrospective Studie, Survival Rate, Tacrolimu, Time Factor, Treatment Outcome

الوصف: Advances in surgical techniques and clinical immunosuppression have led to steadily improving results in pancreas transplantation (PTX). The purpose of this study was to analyze retrospectively the outcomes in patients undergoing solitary PTX with portal-enteric (P-E) drainage and contemporary immunosuppression. From June 1998 through December 2000, we performed 28 solitary PTXs with antibody induction and tacrolimus/mycophenolate mofetil maintenance therapy. The first 13 patients received daclizumab (DAC) induction, while the next 15 received thymoglobulin (rabbit anti-human thymocyte gamma globulin; Thymo) induction. The study group included 13 pancreas alone (PA) and 15 sequential pancreas-after-kidney-transplantations (PAKT). Solitary PTX was performed with P-E drainage in 18 patients and systemic-enteric (S-E) drainage in ten. Patient and pancreas graft survival rates were 96% and 79%, respectively, with a mean follow-up of 22 (range 1-39) months. The 1-year actual death-censored pancreas graft survival rate was 89%. One PAKT patient died with a functioning graft at 1 month; three patients (11%) experienced early graft loss due to thrombosis and were excluded from the immunological analysis, leaving 24 evaluable patients. The incidence of acute rejection was 54%, including 50% in PA and 58% in PAKT recipients ( P=NS). In patients receiving Thymo induction, the rate of acute rejection was slightly lower (43% Thymo vs 70% DAC). Moreover, P-E drainage was associated with a slightly lower rate of acute rejection (44% P-E vs 75% S-E; P=NS). In patients with both Thymo induction and P-E drainage ( n=11), there was a tendency toward less rejection (the incidence of acute rejection was 36%). Two immunological graft losses occurred (one due to non-compliance), both in patients with P-E drainage. Only one patient had a cytomegalovirus (CMV) infection. Event-free survival (no rejection, graft loss, or death) was slightly higher in patients receiving Thymo (47%) than in those on DAC (23%) induction ( P=NS). We can ...

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/12664209; info:eu-repo/semantics/altIdentifier/wos/WOS:000182418700003; volume:16; issue:3; firstpage:154; lastpage:160; numberofpages:7; journal:TRANSPLANT INTERNATIONAL; http://hdl.handle.net/11568/871795Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0037641181

الإتاحة: https://doi.org/10.1007/s00147-002-0510Test-1
http://hdl.handle.net/11568/871795Test

المؤلفون: Reddy, K. S., Stratta, R. J., Shokouh Amiri, M. H., Alloway, R., Gaber, A. O., EGIDI, MARIA FRANCESCA

المساهمون: Reddy, K. S., Stratta, R. J., Shokouh Amiri, M. H., Alloway, R., Egidi, MARIA FRANCESCA, Gaber, A. O.

مصطلحات موضوعية: Adult, Antibiotic Prophylaxi, Anticoagulant, Diabetes Mellitus, Type 1, Drainage, Female, Graft Survival, Human, Immunosuppressive Agent, Incidence, Male, Middle Aged, Pancreas Transplantation, Reoperation, Retrospective Studie, Postoperative Complications

الوصف: BACKGROUND: Despite recent advances, surgical complications remain an important source of morbidity after pancreas transplantation (PTX). Several previous studies have delineated the surgical complications after PTX with systemic-bladder (S-B) drainage, but data are limited regarding the incidence and outcomes of surgical complications after PTX with portal-enteric (P-E) drainage. STUDY DESIGN: We retrospectively studied surgical complications after 83 vascularized PTXs with P-E drainage in 79 patients (65 simultaneous kidney-PTXs [SKPT] and 18 solitary PTXs [SPT], 8 pancreas alone and 10 pancreas after kidney transplantation). Twelve (15%) were retransplants. A surgical complication was defined as the need for repeat laparotomy within the first 3 months after PTX. RESULTS: A total of 53 surgical complications requiring repeat laparotomy occurred in 31 patients (37%). The incidence of surgical complications in SKPT and SPT was 38% and 33%, respectively. The most common indications for repeat laparotomy were: vascular thrombosis in 13% (SKPT 14% and SPT 11%), intraabdominal infection in 10% (SKPT 12% and SPT 0%), intraabdominal bleeding in 8% (SKPT 8% and SPT 11%), and duodenal allograft leak in 4% (SKPT 3% and SPT 6%). Patient survival rates at 1 and 3 years with versus without surgical complications were 84% and 80% versus 94% and 86%, respectively (p = NS). Pancreas graft survival rates at 1 and 3 years with versus without surgical complications were 48% and 44% versus 89% and 76%, respectively (p < 0.0001). The incidence of surgical complications was 45% in the first 42 P-E transplantations performed between 1990 and 1995, compared with 29% in the next 41 transplantations performed during 1996 and 1997 (p = NS). The mean number of repeat laparotomies per patient decreased from 1.2 in the former group to 0.5 in the latter group (p = NS). The incidence rates of vascular thrombosis, intraabdominal infection, and duodenal leak in the former and latter groups were 17% versus 10%, 12% versus 7%, and 2% versus ...

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/10472932; info:eu-repo/semantics/altIdentifier/wos/WOS:000082238700011; volume:189; issue:3; firstpage:305; lastpage:313; numberofpages:9; journal:JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS; http://hdl.handle.net/11568/872235Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0032821390; http://www.sciencedirect.com/science/article/pii/S1072751599001350Test

الإتاحة: https://doi.org/10.1016/S1072-7515Test(99)00135-0
http://hdl.handle.net/11568/872235Test
http://www.sciencedirect.com/science/article/pii/S1072751599001350Test

المؤلفون: EGIDI, MARIA FRANCESCA, Shapiro, R, Khanna, A, Fung, J. J, Corry, R. J.

المساهمون: Egidi, MARIA FRANCESCA, Shapiro, R, Khanna, A, Fung, J. J, Corry, R. J.

مصطلحات موضوعية: Adult, Diabetes Mellitus, Type 1, Diabetic Nephropathie, Female, Graft Rejection, Human, Kidney Transplantation, Male, Middle Aged, Pancreas Transplantation, Biopsy, Needle

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/8539841; info:eu-repo/semantics/altIdentifier/wos/WOS:A1995TM69200045; volume:27; issue:6; firstpage:3055; lastpage:3056; numberofpages:2; journal:TRANSPLANTATION PROCEEDINGS; http://hdl.handle.net/11568/872259Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0029584249

الإتاحة: http://hdl.handle.net/11568/872259Test

المؤلفون: Brayman, K. L, Naji, A, Friedman, A. L, Holland, M. T, Tomaszewski, J. E, Samini, F, Perloff, J, Grossman, R, Barker, C. F., EGIDI, MARIA FRANCESCA

المساهمون: Brayman, K. L, Egidi, MARIA FRANCESCA, Naji, A, Friedman, A. L, Holland, M. T, Tomaszewski, J. E, Samini, F, Perloff, J, Grossman, R, Barker, C. F.

مصطلحات موضوعية: Adult, Antilymphocyte Serum, Azathioprine, Cyclosporine, Diabetes Mellitus, Type 1, Diabetic Nephropathie, Drug Administration Schedule, Follow-Up Studie, Graft Rejection, Graft Survival, Human, Immunosuppression, Kidney Failure, Chronic, Kidney Transplantation, Pancreas Transplantation, Prednisone, Retrospective Studie, Time Factors

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/7940776; info:eu-repo/semantics/altIdentifier/wos/WOS:A1994PM60300016; volume:26; issue:5; firstpage:2525; lastpage:2527; numberofpages:3; journal:TRANSPLANTATION PROCEEDINGS; http://hdl.handle.net/11568/872261Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0028110143

الإتاحة: http://hdl.handle.net/11568/872261Test