دورية أكاديمية
No more hypoglycaemia on days with physical activity and unrestricted diet when using a closed‐loop system for 12 weeks: A post‐hoc secondary analysis of the multicentre randomized controlled Diabeloop WP7 trial
| العنوان: | No more hypoglycaemia on days with physical activity and unrestricted diet when using a closed‐loop system for 12 weeks: A post‐hoc secondary analysis of the multicentre randomized controlled Diabeloop WP7 trial |
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| المؤلفون: | Franc, Sylvia, Benhamou, Pierre‐yves, Borot, Sophie, Chaillous, Lucy, Delemer, Brigitte, Doron, Maeva, Guerci, Bruno, Hanaire, Hélène, Huneker, Erik, Jeandidier, Nathalie, Amadou, Coralie, Renard, Eric, Reznik, Yves, Schaepelynck, Pauline, Simon, Chantal, Thivolet, Charles, Thomas, Claire, Hannaert, Patrick, Charpentier, Guillaume |
| المساهمون: | Centre Hospitalier Sud Francilien, Laboratoire de Biologie de l'Exercice pour la Performance et la Santé (LBEPS), Service de Santé des Armées-Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées Brétigny-sur-Orge (IRBA), Centre d'études et de recherches pour l'intensification du traitement du diabète (CERITD), Centre Hospitalier Universitaire CHU Grenoble (CHUGA), Service d'Hépatologie CHRU Besançon, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Service d'Endocrinologie - Diabète - Nutrition Reims, Université de Reims Champagne-Ardenne (URCA)-Hôpital Robert Debré-Hôpital universitaire Robert Debré Reims (CHU Reims), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service d'Endocrinologie - Diabète - Nutrition CHRU Nancy, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service Diabétologie CHU Toulouse, Pôle Cardiovasculaire et Métabolique CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), DIABELOOP S.A., Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), Université Paris-Saclay, Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Hôpital Côte de Nacre CHU Caen, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Hôpital Sainte-Marguerite CHU - APHM (Hôpitaux Sud ), Centre Hospitalier Lyon Sud CHU - HCL (CHLS), Hospices Civils de Lyon (HCL), Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques U 1082 ( IRTOMIT Poitiers ), Université de Poitiers = University of Poitiers (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 1462-8902. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Archive ouverte du Service de Santé des Armées (HAL) |
| مصطلحات موضوعية: | Artificial pancreas, Closed-loop system, Continuous glucose monitoring, Glycaemic control, Hypoglycaemia, Insulin pump therapy, Physical activity, Physical intervention, Randomized controlled trial, Type 1 diabetes, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; Objective: To investigate the efficacy of the Diabeloop Generation-1 (DBLG1) closed-loop system to control the hypoglycaemia induced by physical activity (PA) in real-life conditions.Methods: This was a post-hoc analysis of the Diabeloop WP7 multicentre randomized controlled trial. Glycaemic outcomes were compared between days with and without PA in 56 patients with type 1 diabetes (T1D) using DBLG1 for 12 weeks. After the patient announces a PA, DBLG1 reduces insulin delivery and, if necessary, calculates the amount of preventive carbohydrates (CHO).Results: Daily time spent in the interstitial glucose range <70 mg/dL was not significantly different between days with and without PA (2.0 ± 1.5% versus 2.2 ± 1.1%) and this regardless of the intensity or duration of the PA. Preventive CHO intake recommended by the system was significantly higher in days with PA (41.1 ± 35.5 versus 21.8 ± 28.5 g/day; P <0.0001), and insulin delivery was significantly lower (31.5 ± 10.5 versus 34.0 ± 10.5 U/day; P <0.0001). The time spent in hyperglycaemia and the glycaemic variation coefficient increased significantly on days with PA.Conclusions: In real-life conditions, the use of DBLG1 avoids PA-induced hypoglycaemia. Insulin adjustments and preventive CHO recommendation may explain this therapeutic benefit. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34009725; hal-03240584; https://hal.science/hal-03240584Test; https://hal.science/hal-03240584/documentTest; https://hal.science/hal-03240584/file/DOM-23-2170.pdfTest; PUBMED: 34009725; PUBMEDCENTRAL: PMC8453744 |
| DOI: | 10.1111/dom.14442 |
| الإتاحة: | https://doi.org/10.1111/dom.14442Test https://hal.science/hal-03240584Test https://hal.science/hal-03240584/documentTest https://hal.science/hal-03240584/file/DOM-23-2170.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.2ECBD7AF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/dom.14442 |
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