دورية أكاديمية
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
| العنوان: | Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. |
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| المؤلفون: | Vijayakrishnan, Jayaram, Studd, James, Broderick, Peter, Kinnersley, Ben, Holroyd, Amy, Law, Philip J, Kumar, Rajiv, Allan, James M, Harrison, Christine J, Moorman, Anthony V, Vora, Ajay, Roman, Eve, Rachakonda, Sivaramakrishna, Kinsey, Sally E, Sheridan, Eamonn, Thompson, Pamela D, Irving, Julie A, Koehler, Rolf, Hoffmann, Per, Nöthen, Markus M, Heilmann-Heimbach, Stefanie, Jöckel, Karl-Heinz, Easton, Douglas F, Pharaoh, Paul DP, Dunning, Alison M, Peto, Julian, Canzian, Frederico, Swerdlow, Anthony, Eeles, Rosalind A, Kote-Jarai, ZSofia, Muir, Kenneth, Pashayan, Nora, Greaves, Mel, Zimmerman, Martin, Bartram, Claus R, Schrappe, Martin, Stanulla, Martin, Hemminki, Kari, Houlston, Richard S, PRACTICAL Consortium |
| بيانات النشر: | Springer Nature //www.nature.com/articles/s41467-018-03178-z#article-info Nature Communications |
| سنة النشر: | 2018 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | genome-wide association studies, paediatric cancer |
| الوصف: | Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/277904Test |
| DOI: | 10.17863/CAM.25240 |
| الإتاحة: | https://doi.org/10.17863/CAM.25240Test https://www.repository.cam.ac.uk/handle/1810/277904Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; Attribution 4.0 International |
| رقم الانضمام: | edsbas.372E71F3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.25240 |
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