التفاصيل البيبلوغرافية
| العنوان: |
Critical assessment of protein intrinsic disorder prediction |
| المؤلفون: |
Necci, Marco, Piovesan, Damiano, Tosatto, Silvio C. E., Hoque, Md Tamjidul, Walsh, Ian, Iqbal, Sumaiya, Vendruscolo, Michele, Sormanni, Pietro, Wang, Chen, Raimondi, Daniele, Sharma, Ronesh, Zhou, Yaoqi, Litfin, Thomas, Galzitskaya, Oxana Valerianovna, Lobanov, Michail Yu., Vranken, Wim, Wallner, Björn, Mirabello, Claudio, Malhis, Nawar, Dosztányi, Zsuzsanna, Erdős, Gábor, Mészáros, Bálint, Gao, Jianzhao, Wang, Kui, Hu, Gang, Wu, Zhonghua, Sharma, Alok, Hanson, Jack, Paliwal, Kuldip, Callebaut, Isabelle, Bitard-Feildel, Tristan, Orlando, Gabriele, Peng, Zhenling, Xu, Jinbo, Wang, Sheng, Jones, David T., Cozzetto, Domenico, Meng, Fanchi, Yan, Jing, Gsponer, Jörg, Cheng, Jianlin, Wu, Tianqi, Kurgan, Lukasz, Promponas, Vasilis J., Tamana, Stella, Marino-Buslje, Cristina, Martínez-Pérez, Elizabeth, Chasapi, Anastasia, Ouzounis, Christos, Dunker, A. Keith, Kajava, Andrey V., Leclercq, Jeremy Y., Aykac-Fas, Burcu, Lambrughi, Matteo, Maiani, Emiliano, Papaleo, Elena, Chemes, Lucia Beatriz, Álvarez, Lucía, González-Foutel, Nicolás S., Iglesias, Valentin, Pujols, Jordi, Ventura, Salvador, Palopoli, Nicolás, Benítez, Guillermo Ignacio, Parisi, Gustavo, Bassot, Claudio, Elofsson, Arne, Govindarajan, Sudha, Lamb, John, Salvatore, Marco, Hatos, András, Monzon, Alexander Miguel, Bevilacqua, Martina, Mičetić, Ivan, Minervini, Giovanni, Paladin, Lisanna, Quaglia, Federica, Leonardi, Emanuela, Davey, Norman, Horvath, Tamas, Kovacs, Orsolya Panna, Murvai, Nikoletta, Pancsa, Rita, Schad, Eva, Szabo, Beata, Tantos, Agnes, Macedo-Ribeiro, Sandra, Manso, Jose Antonio, Pereira, Pedro José Barbosa, Davidović, Radoslav, Veljkovic, Nevena, Hajdu-Soltész, Borbála, Pajkos, Mátyás, Szaniszló, Tamás, Guharoy, Mainak, Lazar, Tamas, Macossay-Castillo, Mauricio, Tompa, Peter |
| بيانات النشر: |
Nature Publishing Group US
Nature Methods |
| سنة النشر: |
2021 |
| المجموعة: |
Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: |
Analysis, /631/114/2398, /631/114/794, /631/45/612, /631/114/2411, /631/114/1305 |
| الوصف: |
Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is crucial that their accuracy is high. The Critical Assessment of protein Intrinsic Disorder prediction (CAID) experiment was established as a community-based blind test to determine the state of the art in prediction of intrinsically disordered regions and the subset of residues involved in binding. A total of 43 methods were evaluated on a dataset of 646 proteins from DisProt. The best methods use deep learning techniques and notably outperform physicochemical methods. The top disorder predictor has Fmax = 0.483 on the full dataset and Fmax = 0.792 following filtering out of bona fide structured regions. Disordered binding regions remain hard to predict, with Fmax = 0.231. Interestingly, computing times among methods can vary by up to four orders of magnitude. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf; text/xml |
| اللغة: |
English |
| العلاقة: |
https://www.repository.cam.ac.uk/handle/1810/322151Test |
| DOI: |
10.17863/CAM.69610 |
| الإتاحة: |
https://doi.org/10.17863/CAM.69610Test
https://www.repository.cam.ac.uk/handle/1810/322151Test |
| رقم الانضمام: |
edsbas.428C66 |
| قاعدة البيانات: |
BASE |
