دورية أكاديمية
Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia.
| العنوان: | Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia. |
|---|---|
| المؤلفون: | Boel, Judith A, de Bie, Rob MA, Schmand, Ben A, Dalrymple-Alford, John C, Marras, Connie, Adler, Charles H, Goldman, Jennifer G, Tröster, Alexander I, Burn, David J, Litvan, Irene, Geurtsen, Gert J, MDS Study Group Mild Cognitive Impairment in Parkinson's Disease |
| بيانات النشر: | Wiley //dx.doi.org/10.1002/mdc3.13451 Mov Disord Clin Pract |
| سنة النشر: | 2022 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Parkinson's disease, dementia, diagnostic accuracy, global cognitive tests, mild cognitive impairment |
| الوصف: | BACKGROUND: The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown. METHODS: The MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to define PD-MCI (n = 467). Risk for developing PDD was examined using a Cox model. Global cognitive tests were compared to neuropsychological test batteries (Level I&II) in determining risk for PDD. RESULTS: PD-MCI based on a global cognitive test (MMSE or MoCA) increases the hazard for developing PDD (respectively HR = 2.57, P = 0.001; HR = 4.14, P = <0.001). The C-statistics for MMSE (0.72) and MoCA (0.70) were lower than those based on neuropsychological tests (Level I = 0.82; Level II = 0.81). Sensitivity, specificity and diagnostic accuracy balance was best in Level II. CONCLUSION: MMSE and MoCA predict conversion to PDD. However, Level II neuropsychological assessment seems the preferred assessment for PD-MCI. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Electronic-eCollection; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/339531Test |
| DOI: | 10.17863/CAM.86945 |
| الإتاحة: | https://doi.org/10.17863/CAM.86945Test https://www.repository.cam.ac.uk/handle/1810/339531Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.BB702D8D |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.86945 |
|---|