دورية أكاديمية
Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.
| العنوان: | Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response. |
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| المؤلفون: | Burton, Nicholas O, Dwivedi, Vivek K, Burkhart, Kirk B, Kaplan, Rebecca EW, Baugh, L Ryan, Horvitz, H Robert |
| بيانات النشر: | Springer Science and Business Media LLC //dx.doi.org/10.1038/s41467-018-07640-w Nat Commun |
| سنة النشر: | 2018 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cloning, Molecular, Embryo, Nonmammalian, Embryonic Development, Forkhead Transcription Factors, Gene Expression Regulation, Developmental, Insulin, Lysophosphatidylcholines, Mutagenesis, Nerve Tissue Proteins, Neurotransmitter Agents, Osmotic Pressure, RNA, Messenger, Receptor, Receptors, Cytoplasmic and Nuclear, Sensory Receptor Cells, Signal Transduction, Starvation, Stress, Physiological, Sulfotransferases |
| الوصف: | Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a variety of internal and environmental stimuli. For example, the inhibition of insulin-like signaling in C. elegans mediates its response to both osmotic stress and starvation. We report that in response to osmotic stress the cytosolic sulfotransferase SSU-1 antagonizes insulin-like signaling and promotes developmental arrest. Both SSU-1 and the DAF-16 FOXO transcription factor, which is activated when insulin signaling is low, are needed to drive specific responses to reduced insulin-like signaling. We demonstrate that SSU-1 functions in a single pair of sensory neurons to control intercellular signaling via the nuclear hormone receptor NHR-1 and promote both the specific transcriptional response to osmotic stress and altered lysophosphatidylcholine metabolism. Our results show the requirement of a sulfotransferase-nuclear hormone receptor neurohormonal signaling pathway for some but not all consequences of reduced insulin-like signaling. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Electronic; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/289250Test |
| DOI: | 10.17863/CAM.36512 |
| الإتاحة: | https://doi.org/10.17863/CAM.36512Test https://www.repository.cam.ac.uk/handle/1810/289250Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.23EE4EAC |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.36512 |
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