دورية أكاديمية
Primary post-transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 paediatric patients.
| العنوان: | Primary post-transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 paediatric patients. |
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| المؤلفون: | Taj, Mary M, Maecker-Kolhoff, Britta, Ling, Rebecca, Bomken, Simon, Burkhardt, Birgit, Chiang, Alan KS, Csoka, Monika, Füreder, Anna, Haouy, Stéphanie, Lazic, Jelena, Miakova, Natalia, Minard-Colin, Veronique, Turner, Suzanne D, Uyttebroeck, Anne, Attarbaschi, Andishe, European Intergroup for Childhood Non-Hodgkin’s Lymphoma (EICNHL), the international Berlin-Frankfurt-Münster (i-BFM) Study Group |
| بيانات النشر: | Wiley //dx.doi.org/10.1111/bjh.17398 Br J Haematol |
| سنة النشر: | 2021 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | central nervous system, outcome, post-transplant lymphoproliferative disorder, transplant, treatment, Adolescent, Adult, Allografts, Brain Neoplasms, Child, Preschool, Disease-Free Survival, Female, Hematopoietic Stem Cell Transplantation, Humans, Infant, Injections, Spinal, Lymphoproliferative Disorders, Male, Organ Transplantation, Rituximab, Survival Rate |
| الوصف: | Primary central nervous system (CNS) post-transplant lymphoproliferative disorder (PTLD) in childhood is rare. Twenty-five patients were retrieved from nine European Intergroup for Childhood Non-Hodgkin's Lymphoma and/or international Berlin-Frankfurt-Münster Study Group members. Types of allografts included kidney (n = 11), liver (n = 4), heart (n = 5), bowel (n = 1) and haematopoietic stem cells (n = 4). Eighteen were male, 16 ≥ 10 years old, 21 had monomorphic disease and 24 solid intracranial tumour masses. Four-year event-free and overall survival rates were 50% ± 10% and 74% ± 9% respectively. This report represents the largest paediatric series of CNS PTLD reported to date, showing favourable survival odds following systemic and intrathecal chemotherapy and rituximab administration. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/317822Test |
| DOI: | 10.17863/CAM.64937 |
| الإتاحة: | https://doi.org/10.17863/CAM.64937Test https://www.repository.cam.ac.uk/handle/1810/317822Test |
| حقوق: | All rights reserved |
| رقم الانضمام: | edsbas.A9A5FA76 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.64937 |
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