دورية أكاديمية
Establishing two principal dimensions of cognitive variation in Logopenic Progressive Aphasia
| العنوان: | Establishing two principal dimensions of cognitive variation in Logopenic Progressive Aphasia |
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| المؤلفون: | Ramanan, Siddharth, Roquet, Daniel, Goldberg, Zoë-lee, Hodges, John R, Piguet, Olivier, Irish, Muireann, Lambon Ralph, Matthew A |
| بيانات النشر: | //dx.doi.org/10.1093/braincomms/fcaa125 Brain Communications Oxford University Press |
| سنة النشر: | 2020 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | executive functioning, language, primary progressive aphasia, principal component analysis, visuospatial functioning |
| الوصف: | Logopenic Progressive Aphasia (LPA) is a neurodegenerative syndrome characterised by sentence repetition and naming difficulties arising from left-lateralised temporoparietal atrophy. Clinical descriptions of LPA largely concentrate on profiling language deficits, however, accumulating evidence points to the presence of cognitive deficits, even on tasks with minimal language demands. Although non-linguistic cognitive deficits in LPA are thought to scale with disease severity, patients at discrete stages of language dysfunction display overlapping cognitive profiles, suggesting individual-level variation in cognitive performance, independent of primary language dysfunction. To address this issue, we used principal component analysis to decompose individual-level variation in cognitive performance in 43 well-characterised LPA patients who underwent multi-domain neuropsychological assessments and structural neuroimaging. The principal component analysis solution revealed the presence of two, statistically independent factors, providing stable and clinically intuitive explanations for the majority of variance in cognitive performance in the syndrome. Factor 1 reflected ‘speech production and verbal memory’ deficits which typify LPA. Systematic variations were also confirmed on a second, orthogonal factor mainly comprising visuospatial and executive processes. Adopting a case-comparison approach, we further demonstrate that pairs of patients with comparable Factor 1 scores, regardless of their severity, diverge considerably on visuo-executive test performance, underscoring the inter-individual variability in cognitive profiles in comparably ‘logopenic’ patients. Whole-brain voxel-based morphometry analyses revealed that speech production and verbal memory factor scores correlated with left middle frontal gyrus, while visuospatial and executive factor scores were associated with grey matter intensity of right-lateralised temporoparietal, middle frontal regions and their underlying white matter connectivity. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/311571Test |
| DOI: | 10.17863/CAM.58663 |
| الإتاحة: | https://doi.org/10.17863/CAM.58663Test https://www.repository.cam.ac.uk/handle/1810/311571Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.60689306 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.58663 |
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