دورية أكاديمية
Improved Syntheses of the Mglu₅ Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling.
| العنوان: | Improved Syntheses of the Mglu₅ Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling. |
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| المؤلفون: | Mu, Boshuai, Mu, Linjing, Schibli, Roger, Ametamey, Simon M, Milicevic Sephton, Selena |
| بيانات النشر: | MDPI AG //dx.doi.org/10.3390/ph11010024 Pharmaceuticals (Basel) |
| سنة النشر: | 2018 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | MMPEP, MTEP, Sonogashira cross-coupling, mGlu5 antagonist |
| الوصف: | The Sonogashira cross-coupling, a key step in the syntheses of the mGlu₅ antagonists MMPEP and MTEP, provided an improved three-step method for the preparation of MMPEP in 62% overall yield. Using Spartan molecular modeling kit an explanation for the failure to employ analogues method in the synthesis of MTEP was sought. The DFT calculations indicated that meaningful isolated yields were obtained when the HOMO energy of the aryl halide was lower than the HOMO energy of the respective alkyne. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Electronic; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/290894Test |
| DOI: | 10.17863/CAM.38078 |
| الإتاحة: | https://doi.org/10.17863/CAM.38078Test https://www.repository.cam.ac.uk/handle/1810/290894Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.C5C92655 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.38078 |
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