دورية أكاديمية
Counterregulatory hormone and symptom responses to hypoglycaemia in people with type 1 diabetes, insulin-treated type 2 diabetes or without diabetes: the Hypo-RESOLVE hypoglycaemic clamp study.
| العنوان: | Counterregulatory hormone and symptom responses to hypoglycaemia in people with type 1 diabetes, insulin-treated type 2 diabetes or without diabetes: the Hypo-RESOLVE hypoglycaemic clamp study. |
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| المؤلفون: | Fabricius, Therese W, Verhulst, Clementine EM, Kristensen, Peter L, Holst, Jens J, Tack, Cees J, McCrimmon, Rory J, Heller, Simon R, Evans, Mark L, de Galan, Bastiaan E, Pedersen-Bjergaard, Ulrik, Hypo-RESOLVE consortium |
| بيانات النشر: | Springer Science and Business Media LLC //dx.doi.org/10.1007/s00592-024-02239-8 Acta Diabetol |
| سنة النشر: | 2024 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Counterregulatory response, Diabetes, Hyperinsulinaemic–hypoglycaemic clamp, Hypoglycaemia, Humans, Diabetes Mellitus, Type 1, Type 2, Male, Female, Hypoglycemia, Glucose Clamp Technique, Middle Aged, Adult, Insulin, Glucagon, Hypoglycemic Agents, Blood Glucose, Epinephrine, Aged, Case-Control Studies |
| الوصف: | Acknowledgements: The authors thank Stine Tving Kjøller, Charlotte Hansen, Pernille Banck-Petersen and Rikke Carstensen for assisting as research nurses and Charlotte Pietraszek and Susanne Månsson for preparation of blood and other practicalities during the clamp in Denmark. We also thank Evertine Abbink, Linda Drenthen, Karin Saini, Marjolein Eybergen, Emma Lensen and Esther Eggenhuizen for assistance during the clamps in the Netherlands. ; Funder: National Health Service in the East of England through the Clinical Academic Reserve ; Funder: Copenhagen University ; AIM: The sympathetic nervous and hormonal counterregulatory responses to hypoglycaemia differ between people with type 1 and type 2 diabetes and may change along the course of diabetes, but have not been directly compared. We aimed to compare counterregulatory hormone and symptom responses to hypoglycaemia between people with type 1 diabetes, insulin-treated type 2 diabetes and controls without diabetes, using a standardised hyperinsulinaemic-hypoglycaemic clamp. MATERIALS: We included 47 people with type 1 diabetes, 15 with insulin-treated type 2 diabetes, and 32 controls without diabetes. Controls were matched according to age and sex to the people with type 1 diabetes or with type 2 diabetes. All participants underwent a hyperinsulinaemic-euglycaemic-(5.2 ± 0.4 mmol/L)-hypoglycaemic-(2.8 ± 0.13 mmol/L)-clamp. RESULTS: The glucagon response was lower in people with type 1 diabetes (9.4 ± 0.8 pmol/L, 8.0 [7.0-10.0]) compared to type 2 diabetes (23.7 ± 3.7 pmol/L, 18.0 [12.0-28.0], p < 0.001) and controls (30.6 ± 4.7, 25.5 [17.8-35.8] pmol/L, p < 0.001). The adrenaline response was lower in type 1 diabetes (1.7 ± 0.2, 1.6 [1.3-5.2] nmol/L) compared to type 2 diabetes (3.4 ± 0.7, 2.6 [1.3-5.2] nmol/L, p = 0.001) and controls (2.7 ± 0.4, 2.8 [1.4-3.9] nmol/L, p = 0.012). Growth hormone was lower in people with type 2 diabetes than in type 1 diabetes, at baseline (3.4 ± 1.6 vs 7.7 ± 1.3 mU/L, p = 0.042) and during hypoglycaemia (24.7 ± 7.1 vs ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/zip; text/xml; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/367703Test |
| الإتاحة: | https://www.repository.cam.ac.uk/handle/1810/367703Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.55E8334F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |