دورية أكاديمية
Comprehensive biomarker analysis of patients with idiopathic pulmonary fibrosis and interstitial lung disease with healthy individuals
| العنوان: | Comprehensive biomarker analysis of patients with idiopathic pulmonary fibrosis and interstitial lung disease with healthy individuals |
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| المؤلفون: | Balci, A., Duz, M. E., Vurmaz, A., cilekar, S., Kaya, F. |
| بيانات النشر: | Verduci Publisher |
| سنة النشر: | 2023 |
| المجموعة: | Amasya University Institutional Repository (DSpace@Amasya) |
| مصطلحات موضوعية: | Interstitial lung disease, Idiopathic pulmonary fibrosis, Biomarkers, Oxidative stress, Lung inflammation |
| الوصف: | OBJECTIVE: Interstitial lung dis-eases (ILDs) are a group of diffuse parenchymal lung disorders that can be idiopathic [idiopath-ic pulmonary fibrosis (IPF)] or associated with other diseases and are characterized by varying degrees of inflammation and fibrosis with poor prognosis. Several indicators are essential in di-agnosing these individuals and differentiating between IPF and ILD. PATIENTS AND METHODS: The study in -volved 44 IPF patients, 22 ILD (non-IPF) patients, and 24 healthy people. We aimed to compare ILD (non-IPF) and IPF patient groups with each other and with healthy people in terms of interleukin (IL)-1, tumor necrosis factor-alpha (TNF-& alpha;), ma-trix metalloproteinase (MMP)-1, MMP-7, galec-tin (Gal)-3, IL-6, Krebs von den Lungen-6 (KL -6), total antioxidant status (TAS), total oxidant status (TOS), pyruvate kinase (PK), complete blood count (CBC), ferritin, erythrocyte sedi-mentation rate (ESR), and C-reactive protein (CRP) features. Furthermore, it was intended to assess the patient groups in terms of visu-al semi-quantitative score (VSQS) (IPF alone), respiratory function tests (RFT), and 6-minute walk test (6MWT), also potential correlations be-tween these tests and the previously indicated parameters.RESULTS: MMP-1, MMP-7, Gal-3, IL-6, KL-6, forced vital capacity (FVC), % FVC, forced expi-ratory volume in 1 second (FEV1), % FEV1, TAS, TOS, and PK values significantly elevated in IPF and ILD. Weight, IL-1, MMP-1, MMP-7, Gal-3, IL -6, KL-6, % FVC, FEV1, % FEV1, eosinophil count, and % red blood cell distribution width (RDW) val-ues differed between IPF and ILD. VSQS, 6MWT, and PK were substantially linked with MMP-1, MMP-7, Gal-3, IL-6, and KL-6 in IPF. CONCLUSIONS: The factors investigated can be helpful in the diagnosis and distinc-tion of IPF and ILD. In addition to focusing on the inflammatory environment in IPF and ILD patients, oxidant and antioxidant interactions must be studied. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1128-3602 |
| العلاقة: | European Review For Medical And Pharmacological Sciences; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.12450/2818Test; 27; 12; 5468; 5479; WOS:001035764900015 |
| الإتاحة: | https://doi.org/20.500.12450/2818Test https://hdl.handle.net/20.500.12450/2818Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.174CC5A4 |
| قاعدة البيانات: | BASE |
| تدمد: | 11283602 |
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