دورية أكاديمية
Low Sensitivity of T-Cell Based Detection of Tuberculosis among HIV Co-Infected Tanzanian In-Patients
| العنوان: | Low Sensitivity of T-Cell Based Detection of Tuberculosis among HIV Co-Infected Tanzanian In-Patients |
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| المؤلفون: | Seshadri, C, Uiso, LO, Ostermann, J, Diefenthal, H, Shao, HJ, Chu, HY, Asmuth, DM, Thielman, NM, Bartlett, JA, Crump, JA |
| المصدر: | East African Medical Journal; Vol 85, No 9 (2008); 442-449 ; 0012-835X |
| بيانات النشر: | Kenya Medical Association |
| سنة النشر: | 2008 |
| المجموعة: | AJOL - African Journals Online |
| الوصف: | Objective: To evaluate the performance of QuantiFERON-TB GOLD (QFTG) in a resource-poor setting among patients with and without HIV infection.Design: Cross-sectional study.Setting: Two hospitals in Northern Tanzania.Subjects: Eighty three adult male and female inpatients.Intervention: All patients were screened for HIV infection and underwent tuberculin skin test (TST) and QFTG.Results: Eighty-three subjects were enrolled, and 29 (35%) of 83 were HIV-infected. QFTG yielded indeterminate results in 12 (22%; 95%CI 12%-34%) of 54 HIV-uninfected and 13 (45%; 95%CI 26%-64%) of 29 HIV-infected subjects (p=0.0323). Among those with smear-positive pulmonary tuberculosis, TST was positive in 40 (100%; 95%CI 91%-100%) of 40 HIV-uninfected subjects compared with seven (54%; 95%CI 25%- 81%) of 13 HIV-infected subjects (p<0.0001), and QFTG was positive in 28(70%; 95%CI 53%-83%) of 40 HIV-uninfected subjects compared with three (23%; 95%CI 5%-54%) of 13 HIV-infected subjects (p=0.0029). Among medical inpatients at risk for latent tuberculosis infection, TST was positive in seven (50%) of 14 HIV-uninfected patients and three (19%) of 16 HIV-infected patients (p=0.0701) and QFTG was positive among two (14%) of 14 HIV-uninfected patients and three (19%) of 16 HIV-infected patients (p=0.7437).Conclusions: The presence of HIV co-infection was associated with a significant reduction in sensitivity of both the TST (p<0.0001) and QFTG (p=0.0029) for the diagnosis of active M.tuberculosis infection. The high proportion of indeterminate QFTG and lack of sensitivity, particularly among HIV-infected patients, may limit its applicability in settings like Tanzania. Larger studies in resource-poor settings are required. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://www.ajol.info/index.php/eamj/article/view/117085/106654Test; http://www.ajol.info/index.php/eamj/article/view/117085Test |
| DOI: | 10.4314/eamj.v85i9.117085 |
| الإتاحة: | https://doi.org/10.4314/eamj.v85i9.117085Test http://www.ajol.info/index.php/eamj/article/view/117085Test |
| حقوق: | Copyright for articles published in this journal is retained by the journal. |
| رقم الانضمام: | edsbas.44085806 |
| قاعدة البيانات: | BASE |
| DOI: | 10.4314/eamj.v85i9.117085 |
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