التفاصيل البيبلوغرافية
| العنوان: |
Interleukin-6 gene -572G/C polymorphism and prostate cancer risk |
| المؤلفون: |
Wang, Yingwei, Chen, Xin, Chen, Yafei |
| المصدر: |
African Health Sciences; Vol 18, No 2 (2018); 267-272 ; 1680-6905 |
| بيانات النشر: |
Makerere University Medical School (Uganda) |
| سنة النشر: |
2018 |
| المجموعة: |
AJOL - African Journals Online |
| مصطلحات موضوعية: |
Prostate cancer, IL-6 polymorphisms, risk |
| الوصف: |
Background: The aim of the present study was to determine whether the interleukin-6 (IL-6) -572G/C polymorphism correlates with prostate cancer.Methods: According to inclusion and exclusion criteria, the association of the IL-6 -572G/C polymorphism with prostate cancer was searched in databases and analyzed using comprehensive meta-analysis software. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.Results: We considered a total of six case-control studies including 2237 patients and 1754 controls and the meta-analysis results showed significant association between the IL-6 -572G/C polymorphism and prostate cancer risk(CC vs GG: OR = 0.49, 95% CI =0.37-0.65;CG vs GG: OR =0.71, 95% CI = 0.58-0.87; the dominant model: OR =0.65, 95% CI = 0.54-0.79;the recessive model: OR =0.70, 95% CI = 0.58-0.85). In stratified analyses by ethnicity, significant associations were found among Asian populations. However, no significant association was found in Caucasian populations.Conclusion: Our findings demonstrated that the -572G/C polymorphism of the IL-6 gene may be a risk factor for the development of prostate cancer in Asians.Keywords: Prostate cancer, IL-6 polymorphisms, risk. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://www.ajol.info/index.php/ahs/article/view/173603/163036Test; https://www.ajol.info/index.php/ahs/article/view/173603Test |
| الإتاحة: |
https://www.ajol.info/index.php/ahs/article/view/173603Test |
| حقوق: |
A. AFRICAN HEALTH SCIENCES OPEN ACCESS POLICYWhile African Health Sciences has been freely accessible online there have been questions on whether it is Open Access or not. We wish to clearly state that indeed African Health Sciences is Open Access. There are key issues regarding Open Access needing clarification for avoidance of doubt:1. Henceforth, papers in African Health Sciences will be published under the CC BY (Creative Commons Attribution License) 4.0 International. See details on https://creativecomons.orgTest/)2. The copyright owners or the authors grant the 3rd party (perpetually and in advance) the right to disseminate, reproduce, or use the research papers in part or in full, format/medium as long as:No substantive errors are introduced in the processAttribution of authorship and correct citation details are givenThe referencing details are not changed. Should the papers be reproduced in part, this must be clearly stated.3. The papers will be freely and universally accessible online in an easily readable format such as XML in at least one widely recognized open access repository such as PUBMED CENTRAL.B. ABRIDGED LICENCE AGREEMENT BETWEEN AUTHORS AND African Health SciencesI submitted my manuscript to African Health Sciences and would like to affirm that: 1.0 I am authorized by my co-authors to enter into these arrangements.2.0 I guarantee, on behalf of self and co-authors:That the paper is original, and has not been published in any other peer-reviewed journal; nor is it under consideration by other journal (s). It does not infringe existing copyright or any other person’s rights That we are/I am the sole author(s) of the paper and with authority to enter into this agreement. My granting rights to African Health Sciences is not in breach of any other obligation That the paper contains nothing unlawful, or libelous. Nor anything that would constitute a breach of contract, confidence or commitment given to secrecy, if published That I/we have taken care to ensure the integrity of the article.3.0 I and all co-authors, agree that the paper, if accepted for publication, shall be licensed under the Creative Commons Attribution License 4.0. (see https://creativecommons.orgTest/) |
| رقم الانضمام: |
edsbas.611D697E |
| قاعدة البيانات: |
BASE |
