دورية أكاديمية
Cerebral Microbleeds Assessment and Quantification in COVID-19 Patients With Neurological Manifestations
| العنوان: | Cerebral Microbleeds Assessment and Quantification in COVID-19 Patients With Neurological Manifestations |
|---|---|
| المؤلفون: | Remuzzi, Andrea |
| المساهمون: | Napolitano, Angela, Arrigoni, Alberto, Caroli, Anna, Cava, Mariangela, Remuzzi, Andrea, Longhi, Luca Giovanni, Barletta, Antonino, Zangari, Rosalia, Lorini, Ferdinando Luca, Sessa, Maria, Gerevini, Simonetta |
| سنة النشر: | 2022 |
| المجموعة: | Aisberg - Archivio istituzionale dell'Università di Bergamo |
| مصطلحات موضوعية: | MRI, cerebral microbleeds (CMBs), inflammation, neuro-COVID, susceptibility-weighted imaging (SWI), Settore ING-IND/34 - Bioingegneria Industriale |
| الوصف: | It is increasingly acknowledged that Coronavirus Disease 2019 (COVID-19) can have neurological manifestations, and cerebral microbleeds (CMBs) have been observed in this setting. The aim of this study was to characterize CMBs patterns on susceptibility-weighted imaging (SWI) in hospitalized patients with COVID-19 with neurological manifestations. CMBs volume was quantified and correlated with clinical and laboratory parameters. The study included patients who were hospitalized due to COVID-19, exhibited neurological manifestations, and underwent a brain MRI between March and May 2020. Neurological, clinical, and biochemical variables were reported. The MRI was acquired using a 3T scanner, with a standardized protocol including SWI. Patients were divided based on radiological evidence of CMBs or their absence. The CMBs burden was also assessed with a semi-automatic SWI processing procedure specifically developed for the purpose of this study. Odds ratios (OR) for CMBs were calculated using age, sex, clinical, and laboratory data by logistic regression analysis. Of the 1,760 patients with COVID-19 admitted to the ASST Papa Giovanni XXIII Hospital between 1 March and 31 May 2020, 116 exhibited neurological symptoms requiring neuroimaging evaluation. Of these, 63 patients underwent brain MRI and were therefore included in the study. A total of 14 patients had radiological evidence of CMBs (CMBs+ group). CMBs+ patients had a higher prevalence of CSF inflammation (p = 0.020), a higher white blood cell count (p = 0.020), and lower lymphocytes (p = 0.010); the D-dimer (p = 0.026), LDH (p = 0.004), procalcitonin (p = 0.002), and CRP concentration (p < 0.001) were higher than in the CMBs- group. In multivariable logistic regression analysis, CRP (OR = 1.16, p = 0.011) indicated an association with CMBs. Estimated CMBs volume was higher in females than in males and decreased with age (Rho = -0.38; p = 0.18); it was positively associated with CRP (Rho = 0.36; p = 0.22), and negatively associated with lymphocytes (Rho = ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | remote |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35677326; info:eu-repo/semantics/altIdentifier/wos/WOS:000807210000001; volume:13; firstpage:1; lastpage:12; journal:FRONTIERS IN NEUROLOGY; https://hdl.handle.net/10446/239313Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85131823080 |
| DOI: | 10.3389/fneur.2022.884449 |
| الإتاحة: | https://doi.org/10.3389/fneur.2022.884449Test https://hdl.handle.net/10446/239313Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DB5853E6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fneur.2022.884449 |
|---|