دورية أكاديمية
Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS
| العنوان: | Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS |
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| المؤلفون: | Gulcin, Ilhami, Kaya, Ruya, Goren, Ahmet C., Akincioglu, Hulya, Topal, Meryem, Bingol, Zeynebe, Cakmak, Kader Cetin |
| المساهمون: | Belirlenecek |
| بيانات النشر: | Taylor & Francis Inc |
| سنة النشر: | 2019 |
| المجموعة: | Ağrı İbrahim Çeçen University Institutional Repository (DSpae@Ağrı) |
| مصطلحات موضوعية: | Cinnamon, Cinnamomum verum, antioxidant activity, polyphenol content, LC-MS, MS, In-Vitro Antioxidant, Radical Scavenging Activity, Lyophilized Aqueous Extract, Carbonic-Anhydrase, Antiradical Activities, Antimicrobial Activities, Inhibitory Properties, Analgesic Activities, Crystal-Structure, Oxidative Stress |
| الوصف: | Ethanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum) were evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant methods. Their inhibitory effects were tested against some enzymes including acetylcholinesterase, butyrylcholinesterase, alpha-glycosidase and alpha-amylase, which linked to different diseases. Additionally, the antioxidant properties were determined and polyphenolic compositions of the both extracts were evaluated by LC-MS/MS analysis. According to the LC-MS/MS experiments, thirteen compounds were found in WEC and EEC. Also, p-hydroxybenzoic acid (321.1 mg/kg extract), p-coumaric acid (291.4 mg/kg extract), and pyrogallol (142.4 mg/kg extract) were found to be the most abundant ingredients in the WEC. On the other hand, pyrogallol (264.3 mg/kg extract), ferulic acid (224.7 mg/kg extract) and p-coumaric acid (170.2 mg/kg extract) were found as the most plentiful chemicals in the EEC. For the estimation of the antioxidant capacities of the both extracts (WEC and EEC), DPPH center dot and ABTS(center dot+) scavenging activities, as well as Fe3+-Fe2+, and Cu2+-Cu+ reducing assays were studied. The IC50 values of the WEC and EEC indicated that they were potent effective DPPH center dot (21. 25 and 15.71 mu g/mL) and ABTS(center dot+) (6.52 and 5.79 mu g/mL) scavengers, as well as AChE (221.33 and 110.26 mu g/mL), BChE (461.69 and 94.93 mu g/mL), alpha-glycosidase (206.86 and 220.00 mu g/mL) and alpha-amylase (189.86 and 200.86 mu g/mL) inhibitors. As a conclusion, both EEC and WEC had rich phenolic contents and demonstrated effective anticholinergic, antidiabetic and antioxidant effects. ; Distinguished Scientist Fellowship Program at King Saud University ; S. A would like to extend his sincere appreciation to the Distinguished Scientist Fellowship Program at King Saud University for funding this research. The authors report no conflicts of interest. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1094-2912 1532-2386 |
| العلاقة: | International Journal Of Food Properties; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1080/10942912.2019.1656232Test; https://hdl.handle.net/20.500.12501/2907Test; 22; 1511; 1526; WOS:000483851800001; 2-s2.0-85071676745 |
| DOI: | 10.1080/10942912.2019.1656232 |
| الإتاحة: | https://doi.org/20.500.12501/2907Test https://doi.org/10.1080/10942912.2019.1656232Test https://hdl.handle.net/20.500.12501/2907Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6ABAA92B |
| قاعدة البيانات: | BASE |
| تدمد: | 10942912 15322386 |
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| DOI: | 10.1080/10942912.2019.1656232 |