دورية أكاديمية
The effect of Paraoxonase gene polymorphisms and paraoxonase enzyme activity on Non-Hodgkin lymphoma
| العنوان: | The effect of Paraoxonase gene polymorphisms and paraoxonase enzyme activity on Non-Hodgkin lymphoma |
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| المؤلفون: | Cinar, Ercan, Akgollu, Ersin, Yucebilgic, Guzide, Bilgin, Ramazan, Paydas, Semra |
| المساهمون: | Belirlenecek |
| بيانات النشر: | Taylor & Francis Inc |
| سنة النشر: | 2022 |
| المجموعة: | Ağrı İbrahim Çeçen University Institutional Repository (DSpae@Ağrı) |
| مصطلحات موضوعية: | PON1 variants, Q192R (rs662), L55M (rs854560), non-hodgkin lymphoma, Oxidative Stress, Molecular-Basis, Pon1, Risk, Susceptibility, Exposure, Cancer, Arylesterase, Hydrolysis, Pesticides |
| الوصف: | Non-Hodgkin Lymphoma (NHL) is a malignant lymphoproliferative disease. Antioxidant paraoxonase enzyme (PON1) has a vital role in the elimination of potential carcinogenic organophosphate molecules. The polymorphisms in the PON1 gene, especially Q192R and L55M, may affect negatively the activity and synthesis of PON1 enzyme. The aim of this study was to evaluate the effect of these polymorphisms together with PON1 enzyme activity on NHL. We surveyed these polymorphisms together with PON1 enzyme activity in 93 patients with NHL and in 93 healthy individuals by real-time polymerase chain reaction (RT-PCR) and spectrophotometer. Although carrying the M and R alleles of L55M and Q192R polymorphisms increases the risk of NHL, they were not significant. Furthermore, the NHL patients carrying 192 R allele had significantly lower enzyme activity than controls having same allele (P = 0.025). This research is the first study worldwide investigating the effect of Q192R and L55M polymorphisms on PON1 enzyme activity in NHL disease. The risk of developing NHL may be further increased in individuals with low enzyme activity having R risk allele of the Q192R polymorphism. The present study suggests that these polymorphisms in NHL disease should be analyzed together with PON1 enzyme activity in larger populations. Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2022.2052315Test . ; Cukurova University Research Projects Unit [FEF2011D31] ; This study was supported by Cukurova University Research Projects Unit (FEF2011D31). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1525-7770 1532-2335 |
| العلاقة: | Nucleosides Nucleotides & Nucleic Acids; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1080/15257770.2022.2052315Test; https://hdl.handle.net/20.500.12501/2922Test; 41; 5-6; 489; 502; WOS:000770857300001; 2-s2.0-85126822381 |
| DOI: | 10.1080/15257770.2022.2052315 |
| الإتاحة: | https://doi.org/20.500.12501/2922Test https://doi.org/10.1080/15257770.2022.2052315Test https://hdl.handle.net/20.500.12501/2922Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.28E63F26 |
| قاعدة البيانات: | BASE |
| تدمد: | 15257770 15322335 |
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| DOI: | 10.1080/15257770.2022.2052315 |